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6-氯鸟嘌呤核苷

6-氯鸟嘌呤核苷用途

6-氯鸟嘌呤核苷(6-氯鸟苷)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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6-氯鸟嘌呤核苷名称

[ CAS 号 ]:
2004-07-1

[ 中文名 ]:
6-氯鸟嘌呤核苷

[ 英文名 ]:
6-Chloroguanineriboside

[中文别名 ]:

[英文别名 ]:

6-Chloroguanineriboside
2-Amino-6-chloro-9-(β-D-ribofuranosyl)purine
6-Chloro-9-(β-D-ribofuranosyl)-9H-purin-2-amine
EINECS 217-905-3
(−)-2-Amino-6-chloropurine riboside
6-CHLOROGUANOSINE
2-Amino-6-chloropurine Riboside
6-Chloroguanine nucleoside
6-CHLOROADENOSINE
6-Chloroguanosine2

6-氯鸟嘌呤核苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

6-氯鸟嘌呤核苷物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
729.9±70.0 °C at 760 mmHg

[ 熔点 ]:
165-167 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₁₂ClN₅O₄

[ 分子量 ]:
301.69

[ 闪点 ]:
395.2±35.7 °C

[ 精确质量 ]:
301.057770

[ PSA ]:
139.54000

[ LogP ]:
-0.59

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.912

[ 储存条件 ]:
−20°C

6-氯鸟嘌呤核苷MSDS

6-氯鸟嘌呤核苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

6-氯鸟嘌呤核苷合成路线

6-氯鸟嘌呤核苷上下游产品

6-氯鸟嘌呤核苷上游产品

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6-氯鸟嘌呤核苷文献

Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.

Acta Chem. Scand. B 41 , 701-707, (1987)

D.c. polarography of 2-amino-6-chloropurine in aqueous medium over a broad pH range revealed two diffusion waves, the first of which corresponds to reduction of the C(6)-Cl bond, leading to formation ...

Synthesis of a mutagenic nucleoside, 2'-deoxy-2-(p-nitrophenyl)-adenosine.

Nucleic Acids Symp. Ser. 17 , 141-143, (1986)

The reaction of 2-amino-6-chloropurine riboside with i-amyl nitrite in benzene in the presence of Cu2O, followed by treatment with NH3/MeOH gave 2-phenyladenosine (1). The crude sample of 1 was found ...

Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication.

Nucleosides Nucleotides Nucleic Acids 25 , 655-665, (2006)

A key compound, 2-amino-6-chlor-9-(2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranosyl)puine, was prepared from 2-amino-6-chloropurine riboside in 5 steps, then subjected to the nucleophilic displaceme...

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