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鸟苷

鸟苷用途

Guanosine 是核苷的一种,是由鸟嘌呤与核糖环组成,两者之间由 β-N9-配糖键相连。

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鸟苷名称

[ CAS 号 ]:
118-00-3

[ 中文名 ]:
鸟嘌呤核苷

[ 英文名 ]:
Guanosine

[中文别名 ]:

[英文别名 ]:

MFCD00010182
2-amino-Inosine
Guanosine
9-(β-D-Ribofuranosyl)guanine
guanine riboside
Inosine,2-amino
2-Amino-9-(β-D-ribofuranosyl)-9H-purin-6-ol
EINECS 204-227-8
9-β-D-ribofuranosyl-Guanine
vernine

鸟苷生物活性

[ 描述 ]:

Guanosine 是核苷的一种,是由鸟嘌呤与核糖环组成,两者之间由 β-N9-配糖键相连。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

鸟苷可被磷酸化成鸟苷一磷酸(GMP),环鸟苷一磷酸(cGMP),鸟苷二磷酸(GDP)和鸟苷三磷酸(GTP)。这些形式在各种生物化学过程中起重要作用,例如核酸和蛋白质的合成,光合作用,肌肉收缩和细胞内信号转导(cGMP)。

[相关活性小分子]

鸟苷物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
756.6±70.0 °C at 760 mmHg

[ 熔点 ]:
240ºC

[ 分子式 ]:
C₁₀H₁₃N₅O₅

[ 分子量 ]:
283.241

[ 闪点 ]:
411.4±35.7 °C

[ 精确质量 ]:
283.091675

[ PSA ]:
159.51000

[ LogP ]:
-3.27

[ 外观性状 ]:
细灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.955

[ 储存条件 ]:
2~8°C

鸟苷MSDS

鸟苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8750000

CHEMICAL NAME :: Guanosine

CAS REGISTRY NUMBER :: 118-00-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FMYMVJ GUM D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,52,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9994 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

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鸟苷安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MF8750000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29349990

鸟苷合成路线

鸟苷上下游产品

鸟苷上游产品

鸟苷下游产品

鸟苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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鸟苷