< 生产厂家价格 >

1-(2-嘧啶基)哌嗪

1-(2-嘧啶基)哌嗪用途

2-(1-哌嗪基)嘧啶是坦多螺旋酮(HY-14558)的主要代谢物[1]。

点击显示

1-(2-嘧啶基)哌嗪名称

[ CAS 号 ]:
20980-22-7

[ 中文名 ]:
1-(2-嘧啶基)哌嗪

[ 英文名 ]:
1-(2-PYRIMIDINYL) PIPERAZINE

[中文别名 ]:

[英文别名 ]:

2-piperazin-1-yl-pyrimidine
2-(Piperazin-1-yl)pyrimidin
2-(piperazin-1-yl)pyrimidine
EINECS 244-135-5
Pyrimidine, 2-(1-piperazinyl)-
1-pp
PMPRZ
RARECHEM AH CK 0195
1-(2-Pyrimidinyl)piperazine
2-piperazinopyrimidine

1-(2-嘧啶基)哌嗪生物活性

[ 描述 ]:

2-(1-哌嗪基)嘧啶是坦多螺旋酮(HY-14558)的主要代谢物[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

1-(2-嘧啶基)哌嗪物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
328.0±52.0 °C at 760 mmHg

[ 熔点 ]:
32-34°C

[ 分子式 ]:
C₈H₁₂N₄

[ 分子量 ]:
164.208

[ 闪点 ]:
152.1±30.7 °C

[ 精确质量 ]:
164.106201

[ PSA ]:
41.05000

[ LogP ]:
0.49

[ 外观性状 ]:
在熔点后,透明黄色

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

1-(2-嘧啶基)哌嗪MSDS

详细MSDS(安全技术说明书)

1-(2-嘧啶基)哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9702000

CHEMICAL NAME :: Pyrimidine, 2-(1-piperazinyl)-

CAS REGISTRY NUMBER :: 20980-22-7

BEILSTEIN REFERENCE NO. :: 0151178

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4

MOLECULAR WEIGHT :: 164.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,193,1991

点击显示

1-(2-嘧啶基)哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
UN3259

[ WGK德国 ]:
3

[ RTECS号 ]:
UV9702000

[ 海关编码 ]:
2933990090

1-(2-嘧啶基)哌嗪上下游产品

1-(2-嘧啶基)哌嗪上游产品

1-(2-嘧啶基)哌嗪下游产品

1-(2-嘧啶基)哌嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(2-嘧啶基)哌嗪文献

The significant inhibition on CYP3A caused by radix Aconiti single herb is not observed in the Wutou decoction: The necessity of combination therapy of radix Aconiti.

J. Ethnopharmacol. 170 , 251-4, (2015)

Wutou (WT, Radix Aconiti), the mother root of Aconitum carmichaelii Debx., is a famous Chinese herb against rheumatoid arthritis. In Chinese clinics, PWT is often prepared as a decoction in combinatio...

The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.

Food Chem. Toxicol. 51 , 396-403, (2013)

Aconitum species are widely used to treat rheumatism, cardiovascular diseases, and tumors in China and other Asian countries. The herbs are always used with drugs such as paclitaxel. Aconitine (AC) is...

Intravenous buspirone for the prevention of postoperative nausea and vomiting.

Eur. J. Clin. Pharmacol. 68(11) , 1465-72, (2012)

Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative na...

更多文献