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吡贝地尔

吡贝地尔用途

Piribedil 是一种多巴胺 D2 受体 (D2R) 激动剂,对 hα1A-肾上腺素受体 ( hα1A-AR) 也显示出拮抗作用。

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吡贝地尔名称

[ CAS 号 ]:
3605-01-4

[ 中文名 ]:
吡贝地尔

[ 英文名 ]:
Piribedil

[中文别名 ]:

双哌嘧啶

[英文别名 ]:

Piribedilum [INN-Latin]
Piribedile [DCIT]
3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine
Piribedil
ET 495
Trivastal
MFCD00868264
Trivastan
EU-4200
EINECS 222-764-6

吡贝地尔生物活性

[ 描述 ]:

Piribedil 是一种多巴胺 D2 受体 (D2R) 激动剂,对 hα1A-肾上腺素受体 ( hα1A-AR) 也显示出拮抗作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

D2R, hα1A-AR[1]

[参考文献]

[1]. Mark J. Milla, et al. Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization. JPET, 2001, 297 (3) 876-887.

[相关活性小分子]

吡贝地尔物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
469.4±55.0 °C at 760 mmHg

[ 熔点 ]:
98 °C

[ 分子式 ]:
C₁₆H₁₈N₄O₂

[ 分子量 ]:
298.340

[ 闪点 ]:
237.7±31.5 °C

[ 精确质量 ]:
298.142975

[ PSA ]:
50.72000

[ LogP ]:
2.36

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
2-8°C

吡贝地尔MSDS

详细MSDS(安全技术说明书)

吡贝地尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9704000

CHEMICAL NAME :: Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 3605-01-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H18-N4-O2

MOLECULAR WEIGHT :: 298.38

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1- AT6N DNTJ D- BT6N CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,1151,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

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吡贝地尔安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2934999090

吡贝地尔合成路线

详细合成路线

吡贝地尔上下游产品

吡贝地尔上游产品

吡贝地尔下游产品

吡贝地尔海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%