4-氯邻苯二酚

4-氯邻苯二酚用途

4-Chlorocatechol 是 4-chloro-2-aminophenol (4C2AP) 的主要降解产物。4-Chlorocatechol 也是一种 catechol 1,2-dioxygenases 和chlorocatechol dioxygenase 酶的底物。

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4-氯邻苯二酚名称

[ CAS 号 ]:
2138-22-9

[ 中文名 ]:
4-氯邻苯二酚

[ 英文名 ]:
4-Chlorocatechol

[中文别名 ]:

[英文别名 ]:

4-Chloro-1,2-benzenediol
1,2-Benzenediol, 4-chloro-
4-chloropyrocatechol
1,2-dihydroxy 4-chlorobenzene
4-Chlorobenzene-1,2-diol
Pyrocatechol,4-chloro
EINECS 218-381-9
MFCD00059614
4-Chloro-1,2-dihydroxybenzene
1,2-Benzenediol,4-chloro

4-氯邻苯二酚生物活性

[ 描述 ]:

4-Chlorocatechol 是 4-chloro-2-aminophenol (4C2AP) 的主要降解产物。4-Chlorocatechol 也是一种 catechol 1,2-dioxygenases 和chlorocatechol dioxygenase 酶的底物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Pankaj Kumar Arora, et al. Novel degradation pathway of 4-chloro-2-aminophenol via 4-chlorocatechol in Burkholderia sp. RKJ 800. Environ Sci Pollut Res Int. 2014 Feb;21(3):2298-2304.

[2]. Raffaella Caglio, et al. Fine-tuning of catalytic properties of catechol 1,2-dioxygenase by active site tailoring. Chembiochem. 2009 Apr 17;10(6):1015-24.

4-氯邻苯二酚物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
267.1±20.0 °C at 760 mmHg

[ 熔点 ]:
90-94 °C(lit.)

[ 分子式 ]:
C₆H₅ClO₂

[ 分子量 ]:
144.556

[ 闪点 ]:
115.3±21.8 °C

[ 精确质量 ]:
143.997803

[ PSA ]:
40.46000

[ LogP ]:
2.15

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.629

[ 储存条件 ]:
存放于惰性气体之中;避免空气

4-氯邻苯二酚MSDS

4-氯邻苯二酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1490000

CHEMICAL NAME :: Pyrocatechol, 4-chloro-

CAS REGISTRY NUMBER :: 2138-22-9

BEILSTEIN REFERENCE NO. :: 1907691

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H5-Cl-O2

MOLECULAR WEIGHT :: 144.56

WISWESSER LINE NOTATION :: QR BQ DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07880

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4-氯邻苯二酚安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 1759 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UX1490000

[ 包装等级 ]:
II

[ 海关编码 ]:
2908199090

4-氯邻苯二酚合成路线

4-氯邻苯二酚上下游产品

4-氯邻苯二酚上游产品

4-氯邻苯二酚下游产品

4-氯邻苯二酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

4-氯邻苯二酚文献

Identification of Triclosan-O-Sulfate and other transformation products of Triclosan formed by activated sludge.

Sci. Total Environ. 505 , 39-46, (2014)

Aerobic degradation experiments of Triclosan were performed in activated sludge to identify possible transformation products for this compound. During 7 days, the formation of biotransformation produc...

Characterization of catechol 2,3-dioxygenase from Planococcus sp. strain S5 induced by high phenol concentration.

Acta Biochim. Pol. 59(3) , 345-51, (2012)

This study aimed at characterization of a new catechol 2,3-dioxygenase isolated from a Gram-positive bacterium able to utilize phenol as the sole carbon and energy source. Planococcus sp. strain S5 gr...

Multistep conversion of para-substituted phenols by phenol hydroxylase and 2,3-dihydroxybiphenyl 1,2-dioxygenase.

Appl. Biochem. Biotechnol. 169(7) , 2064-75, (2013)

A multistep conversion system of para-substituted phenols by recombinant phenol hydroxylase (PH(IND)) and 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC(LA-4)) was constructed in this study. Docking stud...

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