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木兰花碱

木兰花碱用途

(+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。

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木兰花碱名称

[ CAS 号 ]:
2141-09-5

[ 中文名 ]:
碘化木兰花碱

[ 英文名 ]:
Magnoflorine

[中文别名 ]:

[英文别名 ]:

Magflorine
escholin
Magnoflorine
Aporphine alkaloid
escholine
Thalictrine
UNII-NI8K6962K4
THALICTRIN
Esholine

木兰花碱生物活性

[ 描述 ]:

(+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 代谢疾病

[ 靶点 ]

Fungal[1]

[参考文献]

[1]. Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167.

[2]. Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.

木兰花碱物理化学性质

[ 熔点 ]:
252ºC

[ 分子式 ]:
C₂₀H₂₄NO₄+

[ 分子量 ]:
342.408

[ 精确质量 ]:
342.169983

[ PSA ]:
58.92000

[ LogP ]:
-1.71

[ 储存条件 ]:
2-8C

木兰花碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ1777600

CHEMICAL NAME :: 4H-Dibenzo(de,g)quinolinium, 5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6 -dimethyl-, (S)-

CAS REGISTRY NUMBER :: 2141-09-5

LAST UPDATED :: 199503

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H24-N-O4

MOLECULAR WEIGHT :: 342.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

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木兰花碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P261-P280-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
HQ1777600