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柔红酮

柔红酮用途

Daunomycinone (NSC-109351) 是 Daunomycin 的代谢物。Daunomycin 是一种抗生素,具有抗肿瘤活性。

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柔红酮名称

[ CAS 号 ]:
21794-55-8

[ 中文名 ]:
柔红酮

[ 英文名 ]:
Daunomycinone

[中文别名 ]:

[英文别名 ]:

daunomycinone

柔红酮生物活性

[ 描述 ]:

Daunomycinone (NSC-109351) 是 Daunomycin 的代谢物。Daunomycin 是一种抗生素,具有抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26.

[2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53.

柔红酮物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
677.4±55.0 °C at 760 mmHg

[ 熔点 ]:
208-210°C

[ 分子式 ]:
C₂₁H₁₈O₈

[ 分子量 ]:
398.36

[ 闪点 ]:
243.4±25.0 °C

[ 精确质量 ]:
398.100159

[ PSA ]:
141.36000

[ LogP ]:
2.93

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.713

[ 储存条件 ]:
-20°C Freezer

柔红酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9295500

CHEMICAL NAME :: 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1 -methoxy-, (8S, 10S)-

CAS REGISTRY NUMBER :: 21794-55-8

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H18-O8

MOLECULAR WEIGHT :: 398.39

WISWESSER LINE NOTATION :: L E6 C666 BV MVT&&&J DQ FQ HV1 HQ KQ RO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 68,115,1978

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柔红酮安全信息

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

柔红酮合成路线

详细合成路线

柔红酮文献

Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells.

Free Radic. Res. 24(1) , 9-18, (1996)

The production of semiquinone free radicals has been measured by electron paramagnetic resonance spectroscopy (EPR) in Chinese hamster ovary cells in which 7-hydroxy daunorubicin aglycone had been inc...

Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius.

J. Basic Microbiol. 26(4) , 249-55, (1986)

Aklanonic acid is an anthracyclinone-related pigment that was found to be an intermediate at an early stage of the biosynthesis of daunomycinone glycosides by Streptomyces griseus. We now isolated ant...

Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.

J. Antibiot. 38(12) , 1714-8, (1985)

Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect ...

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柔红酮