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蛇形菌素标准溶液

蛇形菌素标准溶液用途

Diacetoxyscirpenol (DAS) 是一种单端孢霉烯真菌毒素,是真菌的次生代谢产物。Diacetoxyscirpenol (DAS) 的摄入会引起人类和动物的血液病(中性粒细胞减少、再生障碍性贫血)。
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蛇形菌素标准溶液名称

[ CAS 号 ]:
2270-40-8

[ 中文名 ]:
二乙酰镳草镰刀菌烯醇

[ 英文名 ]:
Diacetoxyscirpenol

[中文别名 ]:

[英文别名 ]:

蛇形菌素标准溶液生物活性

[ 描述 ]:

Diacetoxyscirpenol (DAS) 是一种单端孢霉烯真菌毒素,是真菌的次生代谢产物。Diacetoxyscirpenol (DAS) 的摄入会引起人类和动物的血液病(中性粒细胞减少、再生障碍性贫血)。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[参考文献]

[1]. Lautraite S, et al. In vitro effects of diacetoxyscirpenol (DAS) on human and rat granulo-monocytic progenitors. Mycopathologia. 1997;140(1):59-64.

[2]. Hoerr FJ, et al.Mycotoxicosis caused by a single dose of T-2 toxin or diacetoxyscirpenol in broiler chickens. Vet Pathol. 1981 Sep;18(5):652-64.

蛇形菌素标准溶液物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
471.2±45.0 °C at 760 mmHg

[ 熔点 ]:
162-164℃

[ 分子式 ]:
C19H26O7

[ 分子量 ]:
366.405

[ 闪点 ]:
162.8±22.2 °C

[ 精确质量 ]:
366.167847

[ PSA ]:
94.59000

[ LogP ]:
1.33

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

蛇形菌素标准溶液MSDS

详细MSDS(安全技术说明书)

蛇形菌素标准溶液毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YD0112000
CHEMICAL NAME :
Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 4,15-diacetate
CAS REGISTRY NUMBER :
2270-40-8
LAST UPDATED :
199607
DATA ITEMS CITED :
29
MOLECULAR FORMULA :
C19-H26-O7
MOLECULAR WEIGHT :
366.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
12 mg/kg/5D
TOXIC EFFECTS :
Behavioral - muscle weakness Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 ug/kg
TOXIC EFFECTS :
Cardiac - pulse rate Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - dermatitis, allergic (after topical exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11300 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Gastrointestinal - ulceration or bleeding from small intestine
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7839 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7709 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7762 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1100 ug/kg
TOXIC EFFECTS :
Cardiac - pulse rate Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - dermatitis, allergic (after topical exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - dermatitis, allergic (after topical exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2140 ug/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
3820 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg/8D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg/5W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15120 ug/kg/4W-I
TOXIC EFFECTS :
Blood - normocytic anemia Blood - leukopenia Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
58800 ug/kg/21D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9 mg/kg
SEX/DURATION :
female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1500 ug/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
3 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
5600 ug/kg
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 19,65,1978
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蛇形菌素标准溶液安全信息

[ 危害码 (欧洲) ]:
T+,T,Xn,F

[ 风险声明 (欧洲) ]:
26/27/28-36/38-36-20/21/22-11

[ 安全声明 (欧洲) ]:
S45;S53

[ 危险品运输编码 ]:
UN 3462 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
YD0112000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29329990

蛇形菌素标准溶液合成路线

详细合成路线

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蛇形菌素标准溶液上游产品

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推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

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价格：

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产品详情：蛇形菌素标准溶液

公司名：上海吉至生化科技有限公司

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价格：
￥5778.0/2ml

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价格：
￥需询单/1g

联系人：赖经理

产品详情：Diacetoxyscirpenol

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥401.9/1mg ￥1596.9/5mg ￥4428.9/2ml ￥5561.9/25mg

联系人：阿拉丁

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价格：
￥1.0/10mg ￥1.0/50mg ￥1.0/100mg

联系人：周经理

产品详情：蛇形菌素

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