< 生产厂家价格 >

纳布啡盐酸盐水合物

纳布啡盐酸盐水合物名称

[ CAS 号 ]:
23277-43-2

[ 中文名 ]:
纳布啡盐酸盐水合物

[ 英文名 ]:
Nalbuphine Hydrochloride

[英文别名 ]:

Nalbuphine hydrochloride
Nalbuphine hydrochloride hydrate

纳布啡盐酸盐水合物物理化学性质

[ 沸点 ]:
566.6ºC at 760 mmHg

[ 熔点 ]:
230.5ºC

[ 分子式 ]:
C₂₁H₂₈ClNO₄

[ 分子量 ]:
393.90400

[ 闪点 ]:
296.5ºC

[ 精确质量 ]:
393.17100

[ PSA ]:
73.16000

[ LogP ]:
2.44720

[ 外观性状 ]:
白色至近乎于白色固体

[ 蒸汽压 ]:
1.12E-13mmHg at 25°C

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
H2O: soluble

纳布啡盐酸盐水合物MSDS

纳布啡盐酸盐水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD3181000

CHEMICAL NAME :: Morphinan-3,6-alpha,14-triol, 17-(cyclobutylmethyl)-4,5-alpha-epoxy-, hydrochloride

CAS REGISTRY NUMBER :: 23277-43-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H27-N-O4.Cl-H

MOLECULAR WEIGHT :: 393.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 90,773,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5314 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

点击显示

纳布啡盐酸盐水合物安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311-H330-H370

[ 警示性声明 ]:
P210-P260-P280-P284-P301 + P310-P310

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
QD3181000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

纳布啡盐酸盐水合物合成路线

纳布啡盐酸盐水合物上下游产品

纳布啡盐酸盐水合物上游产品

纳布啡盐酸盐水合物下游产品

纳布啡盐酸盐水合物文献

Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).

Am. J. Vet. Res. 72(6) , 741-5, (2011)

To assess the pharmacokinetics of nalbuphine HCl after IV and IM administration to Hispaniolan Amazon parrots (Amazona ventralis).8 healthy adult Hispaniolan Amazon parrots of unknown sex.Nalbuphine H...

A review of systemic opioids commonly used for labor pain relief.

J. Midwifery Womens. Health 56(3) , 222-39, (2011)

Parenteral opioids for pain relief during labor have been the subject of research for many decades. Commonly used systemic opioids provide limited pain relief during labor yet are used extensively for...

Ultrasound guidance characteristics and efficiency of suprazygomatic maxillary nerve blocks in infants: a descriptive prospective study.

Paediatr. Anaesth. 22(9) , 841-6, (2012)

Bilateral suprazygomatic maxillary nerve blocks approach improves pain relief after palate surgery. We report the feasibility and efficiency of ultrasound-guided suprazygomatic maxillary nerve blocks ...

更多文献