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差向四环素

差向四环素用途

4-表四环素盐酸盐是抗生素四环素的差向异构体。四环素的差向异构体没有催化作用,被认为是降解产物。4-上皮性四环素盐酸盐作为抗生素或Tet抑制效应剂的活性降低,但对动物可能有更强的毒性作用。

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差向四环素名称

[ CAS 号 ]:
23313-80-6

[ 中文名 ]:
差向四环素盐酸盐

[ 英文名 ]:
4-Epitetracycline hydrochloride

[中文别名 ]:

4-盐酸差向四环素

[英文别名 ]:

4-epi-Tetracycline hydrochloride
4-Epitetracycline hydrochloride
2,2,2,2-Propanetetracarbonitrile
4-epi-TetracyclineHydrochloride
MFCD00085371
Epitetracycline hydrochloride
Tetracyanomethane

差向四环素生物活性

[ 描述 ]:

差向四环素物理化学性质

[ 沸点 ]:
682.8ºC at 760mmHg

[ 熔点 ]:
217ºC

[ 分子式 ]:
C₂₂H₂₅ClN₂O₈

[ 分子量 ]:
480.896

[ 闪点 ]:
366.7ºC

[ 精确质量 ]:
480.129944

[ PSA ]:
181.62000

[ LogP ]:
1.28790

[ 外观性状 ]:
Fine Crystalline Powder | Yellow

[ 折射率 ]:
1.74

[ 储存条件 ]:
Amber Vial, -20°C Freezer, Under Inert Atmosphere

差向四环素MSDS

详细MSDS(安全技术说明书)

差向四环素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ1898250

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-4-(dimethylamino)-1,11 -dioxo-6- methyl-3,6,10,12,12a-pentahydroxy-, 4-epimer, hydrochloride

CAS REGISTRY NUMBER :: 23313-80-6

LAST UPDATED :: 199203

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H24-N2-O8.Cl-H

MOLECULAR WEIGHT :: 480.94

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,569,1957

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差向四环素安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H361

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
63-36-36/37/38

[ 安全声明 (欧洲) ]:
36/37/39-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QJ1898250

[ 海关编码 ]:
29413000

差向四环素文献

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012)

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate...

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