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4-氨基吡唑并[3,4-d]嘧啶

4-氨基吡唑并[3,4-d]嘧啶用途

吡唑拉定是一种有效的RET(转染期间重组)肺癌癌蛋白抑制剂。吡唑啉二烯显示出抗癌活性[1][2]。

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4-氨基吡唑并[3,4-d]嘧啶名称

[ CAS 号 ]:
2380-63-4

[ 中文名 ]:
4-氨基吡唑并[3,4-d]嘧啶

[ 英文名 ]:
4-Aminopyrazolo[3,4-d]pyrimidine

[中文别名 ]:

[英文别名 ]:

Methyl 3-piperidinylacetate hydrochloride (1:1)
7-deaza-8-aza-adenine
8-aza-7-deazaadenine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine
1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
EINECS 219-174-6
pyrazolo[3,4-d]pyrimidin-4-amine
Pyrazoloadenine
Aminopurinol
4-aminopyrazolo-(3,4-d)pyrimidine

4-氨基吡唑并[3,4-d]嘧啶生物活性

[ 描述 ]:

吡唑拉定是一种有效的RET(转染期间重组)肺癌癌蛋白抑制剂。吡唑啉二烯显示出抗癌活性[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

[体外研究]

吡唑拉定能抑制多种蛋白激酶,如BTK(布鲁顿酪氨酸激酶)、CDK1/2(细胞周期蛋白依赖性激酶1/2)、Src激酶和RIPK1(受体相互作用蛋白激酶)[1]。

4-氨基吡唑并[3,4-d]嘧啶物理化学性质

[ 密度 ]:
1.612g/cm3

[ 沸点 ]:
431.1ºC at 760mmHg

[ 熔点 ]:
>325 °C(lit.)

[ 分子式 ]:
C₅H₅N₅

[ 分子量 ]:
193.671

[ 闪点 ]:
244.4ºC

[ 精确质量 ]:
193.086960

[ PSA ]:
80.48000

[ LogP ]:
0.51630

[ 外观性状 ]:
米色粉末

[ 储存条件 ]:
-20°C Freezer

4-氨基吡唑并[3,4-d]嘧啶MSDS

详细MSDS(安全技术说明书)

4-氨基吡唑并[3,4-d]嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR0717000

CHEMICAL NAME :: 1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-

CAS REGISTRY NUMBER :: 2380-63-4

BEILSTEIN REFERENCE NO. :: 0005824

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H5-N5

MOLECULAR WEIGHT :: 135.15

WISWESSER LINE NOTATION :: T56 BMN GN INJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 141 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 228 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 22500 mg/kg/9D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Blood - changes in bone marrow (not otherwise specified) Blood - changes in platelet count

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 5 umol/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 48,319,1967

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4-氨基吡唑并[3,4-d]嘧啶安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
UR0717000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

4-氨基吡唑并[3,4-d]嘧啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-氨基吡唑并[3,4-d]嘧啶文献

Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.

J. Neurosci. 35(11) , 4540-51, (2015)

The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in t...

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

J. Clin. Invest. 124(6) , 2585-98, (2014)

Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcri...

Spectroscopic, electronic structure and natural bond analysis of 2-aminopyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine: a comparative study.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 226-41, (2012)

The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stabil...

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