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常山乙素

常山乙素用途

Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,具有抗疟活性。

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常山乙素名称

[ CAS 号 ]:
24159-07-7

[ 中文名 ]:
常山乙素

[ 英文名 ]:
Febrifugine

[中文别名 ]:

[英文别名 ]:

b-Dichroine
β-Dichroine
Febrifugine
febrifungine
Febrifugine (8CI)

常山乙素生物活性

[ 描述 ]:

Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,具有抗疟活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

[2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.

常山乙素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
508.2±60.0 °C at 760 mmHg

[ 熔点 ]:
139-140°; mp 154-156°

[ 分子式 ]:
C₁₆H₁₉N₃O₃

[ 分子量 ]:
301.340

[ 闪点 ]:
261.1±32.9 °C

[ 精确质量 ]:
301.142639

[ PSA ]:
84.22000

[ LogP ]:
-0.04

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.673

[ 储存条件 ]:
2-8℃

常山乙素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3450000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-

CAS REGISTRY NUMBER :: 24159-07-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H19-N3-O3

MOLECULAR WEIGHT :: 301.38

WISWESSER LINE NOTATION :: T66 BVN ENJ C1V1- BT6NTJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948

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常山乙素安全信息

[ 海关编码 ]:
2933990090

常山乙素合成路线

详细合成路线

常山乙素上下游产品

常山乙素上游产品

常山乙素下游产品

常山乙素海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%