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4-氨基-2-氯苯甲酸

4-氨基-2-氯苯甲酸用途

【用途一】
用作医药中间体

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4-氨基-2-氯苯甲酸名称

[ CAS 号 ]:
2457-76-3

[ 中文名 ]:
4-氨基-2-氯苯甲酸

[ 英文名 ]:
2-Chloro-p-aminobenzoic acid

[中文别名 ]:

2-氯-4-氨基苯甲酸

[英文别名 ]:

4-Amino-2-chlorobenzoic acid
Benzoic acid, 4-amino-2-chloro-
EINECS 219-540-5
4-amino-2-chloro-benzoic acid
4-Amino-2-chlor-benzoesaeure
o-Chloro-p-aminobenzoic acid
Benzoic acid,4-amino-2-chloro
2-Chloro-4-aminobenzoic acid
MFCD03407960
2-Chloro-p-aminobenzoic acid

4-氨基-2-氯苯甲酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
365.3±27.0 °C at 760 mmHg

[ 熔点 ]:
211 °C (dec.)(lit.)

[ 分子式 ]:
C₇H₆ClNO₂

[ 分子量 ]:
171.581

[ 闪点 ]:
174.8±23.7 °C

[ 精确质量 ]:
171.008713

[ PSA ]:
63.32000

[ LogP ]:
1.26

[ 外观性状 ]:
米色至淡棕色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
−20°C

4-氨基-2-氯苯甲酸MSDS

4-氨基-2-氯苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575000

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-

CAS REGISTRY NUMBER :: 2457-76-3

BEILSTEIN REFERENCE NO. :: 2803668

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-Cl-N-O2

MOLECULAR WEIGHT :: 171.59

WISWESSER LINE NOTATION :: ZR CG DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 500 mg/L

REFERENCE :: JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947- Volume(issue)/page/year: 18,543,1958

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4-氨基-2-氯苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG1575000

[ 海关编码 ]:
29224995

4-氨基-2-氯苯甲酸合成路线

4-氨基-2-氯苯甲酸上下游产品

4-氨基-2-氯苯甲酸上游产品

4-氨基-2-氯苯甲酸下游产品

4-氨基-2-氯苯甲酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

4-氨基-2-氯苯甲酸文献

Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine.

J. Pharm. Biomed. Anal. 14(8-10) , 1251-9, (1996)

The separation of HPLC of basic drugs on silica-based reversed phases remains a major problem because of the interaction between the residual silanol groups of the silica and the amino function of the...

Intrapartum paracervical block anesthesia with 2-chloroprocaine.

Am. J. Obstet. Gynecol. 146(1) , 16-22, (1983)

Most of the reports of fetal bradycardia and acidosis following paracervical block anesthesia have involved the use of amide-linked anesthetics, such as lidocaine and mepivacaine. The purposes of this...

Comparison of lidocaine and 2-chloroprocaine in paracervical block: clinical effects and drug concentrations in mother and child.

Anesth. Analg. 62(2) , 168-73, (1983)

2-Chloroprocaine (CP) has recently been recommended as a less toxic alternative to amide-type local anesthetics due to its rapid metabolism. A double-blind, randomized study comparing CP to lidocaine ...

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