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(±)-乙酰肉碱氯化物

(±)-乙酰肉碱氯化物用途

(±)-乙酰肉碱氯化物(乙酰-dl-肉碱氯化物)是一种具有胆碱能性质的弱胆碱能激动剂(±)-乙酰肉碱氯化物是脂质代谢的重要中间体[1][2]。

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(±)-乙酰肉碱氯化物名称

[ CAS 号 ]:
2504-11-2

[ 中文名 ]:
乙酰基-dl-肉碱盐酸盐

[ 英文名 ]:
acetyl-dl-carnitine hydrochloride

[英文别名 ]:

rac. Acetylcarnitinchlorid
Acetylcarnitin-chlorid
rac. Acetyl-carnithin
EINECS 219-709-3
O-Acetylcarnitinhydrochlorid
Acetyl dl-carnitine chloride
MFCD00080826
Evans Blue tetrasodium salt
Acetyl-DL-carnitine hydrochloride

(±)-乙酰肉碱氯化物生物活性

[ 描述 ]:

(±)-乙酰肉碱氯化物(乙酰-dl-肉碱氯化物)是一种具有胆碱能性质的弱胆碱能激动剂(±)-乙酰肉碱氯化物是脂质代谢的重要中间体[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

在苍蝇飞行过程中乙酰肉碱浓度的大量增加以及活性乙酰肉碱转移酶的存在表明乙酰肉碱在碳水化合物代谢中很重要。乙酰肉碱是由从脑组织分离出来的胆碱乙酰化酶系统合成的,并被胆碱酯酶破坏[2]。

[体内研究]

在大鼠中,输注2mg(±)-乙酰肉碱氯化物可使通过后肢血管系统的血流减少50%(±)-乙酰肉碱氯化物也增强了肾上腺素对离体兔十二指肠的抑制作用[3]。

[参考文献]

[1]. R A Chalmers, et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. Pediatr Res. 1984 Dec;18(12):1325-8.

[2]. R L Sass, et al. Acetylcarnitine: on the relationship between structure and function. Biochem Biophys Res Commun. 1973 Dec 10;55(3):736-42.

[3]. R T Louis-Ferdinand, et al. Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides. J Pharm Pharmacol. 1970 Sep;22(9):704-5.

(±)-乙酰肉碱氯化物物理化学性质

[ 分子式 ]:
C₉H₁₈ClNO₄

[ 分子量 ]:
239.69700

[ 精确质量 ]:
239.09200

[ PSA ]:
63.60000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
−20°C

(±)-乙酰肉碱氯化物MSDS

详细MSDS(安全技术说明书)

(±)-乙酰肉碱氯化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP2979200

CHEMICAL NAME :: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride, acetate, (+-)-

CAS REGISTRY NUMBER :: 2504-11-2

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H17-N-O4.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959

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(±)-乙酰肉碱氯化物安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BP2979200

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(±)-乙酰肉碱氯化物文献

In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.

J. Nutr. 145(1) , 32-40, (2015)

A large number of birth defects are related to nutrient deficiencies; concern that biotin deficiency is teratogenic in humans is reasonable. Surprisingly, studies indicate that increased urinary 3-hyd...

Sodium-dependent carnitine transport in human placental choriocarcinoma cells.

Biochim. Biophys. Acta 1284 , 109-117, (1996)

The JAR human placental choriocarcinoma cells were found to transport carnitine into the intracellular space by a Na(+)-dependent process. The transport showed no requirement for anions. The Na+-depen...

Photoaffinity labelling of carnitine acetyltransferase with S-(p-azidophenacyl)thiocarnitine.

Biochem. J. 237 , 533-540, (1986)

A photolabile reagent, p-azidophenacyl-DL-thiocarnitine, was synthesized and tested as a photoaffinity label for carnitine acetyltransferase (EC 2.3.1.7) from pigeon breast. p-Azidophenacyl-DL-thiocar...

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