全顺式-4,7,10,13,16-二十二碳五烯酸

全顺式-4,7,10,13,16-二十二碳五烯酸用途

二十二碳五烯酸(DPA)是一种存在于鱼油中的22碳脂肪酸。它是人类血清总不饱和脂肪酸的一个次要成分,含量在0.1%至1%之间,并随着饮食补充而增加。全顺式-4,7,10,13,16-DPA,也称为奥地利酸,是DPA的异构体。它是一种ω-6脂肪酸,由花生四烯酸的延伸和去饱和作用形成。在脂肪酸去饱和酶综合征期间,这种脂肪酸的水平可能会降低,这可能会影响发育。超长脂肪酸蛋白6的肝脏伸长表达上调和超长链脂肪酸水平升高,包括所有顺式4,7,10,13,16-DPA,是非酒精性脂肪性肝炎的特征,非酒精性肝炎是肝细胞癌的癌前疾病。

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全顺式-4,7,10,13,16-二十二碳五烯酸名称

[ CAS 号 ]:
25182-74-5

[ 中文名 ]:
全顺式-4,7,10,13,16-二十二碳五烯酸

[ 英文名 ]:
all-cis-4,7,10,13,16-Docosapentaenoic acid, C22:5n6

[英文别名 ]:

4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid
all-cis-4,7,10,13,16-Docosapentaenoic acid
docosa-4c,7c,10c,13c,16c-pentaenoic acid
Osbond acid
C22:5n-6,9,12,15,18
Docosapentaenoate
cis-4,7,10,13,16-docosapentaenoic acid
docosapentaenoic acid

全顺式-4,7,10,13,16-二十二碳五烯酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

全顺式-4,7,10,13,16-二十二碳五烯酸物理化学性质

[ 密度 ]:
0.932g/cm3

[ 沸点 ]:
443.8ºC at 760mmHg

[ 分子式 ]:
C₂₂H₃₄O₂

[ 分子量 ]:
330.50400

[ 闪点 ]:
340.5ºC

[ 精确质量 ]:
330.25600

[ PSA ]:
37.30000

[ LogP ]:
6.77290

[ 蒸汽压 ]:
4.08E-09mmHg at 25°C

[ 折射率 ]:
1.509

[ 储存条件 ]:
−20°C

全顺式-4,7,10,13,16-二十二碳五烯酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

全顺式-4,7,10,13,16-二十二碳五烯酸文献

Functional characterization of the duck and turkey fatty acyl elongase enzymes ELOVL5 and ELOVL2.

J. Nutr. 144(8) , 1234-9, (2014)

In most Western countries, the consumption of fish is low and insufficient to provide the recommended daily intake of the n-3 (ω-3) long-chain polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid...

Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria.

FASEB J. 23(9) , 2866-71, (2009)

Very long-chain polyunsaturated fatty acids (VLC-PUFAs), such as docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA), have recently made it to the realm of "magical molecules" based on their mu...

Reevaluation of the pathway for the metabolism of 7,10,13, 16-docosatetraenoic acid to 4,7,10,13,16-docosapentaenoic acid in rat liver.

Arch. Biochem. Biophys. 317(1) , 179-84, (1995)

When rat liver microsomes were incubated with [1-14C]22:4(n-6) under standard conditions for measuring acyl-CoA desaturases, it was not possible to detect the synthesis of any 22:5(n-6). When malonyl-...

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