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食品黑1

食品黑1用途

食用黑色色素。

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食品黑1名称

[ CAS 号 ]:
2519-30-4

[ 中文名 ]:
食品黑 1

[ 英文名 ]:
Brilliant Black BN

[中文别名 ]:

[英文别名 ]:

Brilliant Black BN
EINECS 219-746-5
1743black
E151
blueblackbn
C.I. food black 1
l-schwarz1
Food Black 1
MFCD00078980
melanblack

食品黑1生物活性

[ 描述 ]:

Brilliant black BN (E151) 是一种偶氮染料 dye 和一种食品着色剂。Brilliant black BN (E151) 是一种很有前途的抗病毒试剂 (antiviral agent ),通过抑制 EV71 与其细胞脱衣因子亲环素a的相互作用来对抗 EV71 感染。Brilliant black BN (E151) 有潜力用于传染性疾病的相关研究。

[ 相关类别 ]:

研究领域 >> 感染

[ 靶点 ]

IC50: 2.39 µM- 28.12 µM (various strains of EV71)[2]

[体外研究]

亮黑色BN(E151)抑制EV71与其细胞非涂层因子亲环素A的相互作用[1]。明亮的黑色BN(E151)在浓度为300μM时抑制了感染EV71-GFP,这从减少的GFP信号可以证明。亮黑BN(E151)对感染的RD细胞呈剂量依赖性抑制EV71-GFP,IC50值为10.1μM[1]。亮黑BN(E151)对28株EV71、CVA16和CVA6菌株均有抑制作用。在横纹肌肉瘤细胞中,E151染料对各种EV71菌株的50%抑制浓度为2.39μM至28.12μM,而其50%细胞毒性浓度为1870μM[1]。

[体内研究]

亮黑色BN(E151)(腹腔注射；200 mg/kg；14天)表现为轻度疾病,临床评分小于3分,随后与PBS比较恢复-组。全部E151270小鼠在整个实验过程中受到完全保护[1]。动物模型：14日龄AG129小鼠,给予EV71[1]剂量：200mg/kg,腹腔注射。结果：用染料E151对EV71攻击的AG129小鼠有保护作用。

[参考文献]

[1]. Lang W, et al. Biodecolorization of a food azo dye by the deep sea Dermacoccus abyssi MT1.1(T) strain from the Mariana Trench.J Environ Manage. 2014 Jan;132:155-64.

[2]. Meng T, et al. In Vitro and In Vivo Inhibition of the Infectivity of Human Enterovirus 71 by a Sulfonated Food Azo Dye, Brilliant Black BN.J Virol. 2019 Aug 13;93(17).

食品黑1物理化学性质

[ 分子式 ]:
C₂₈H₁₇N₅Na₄O₁₄S₄

[ 分子量 ]:
867.679

[ 精确质量 ]:
866.924561

[ PSA ]:
361.09000

[ LogP ]:
8.50040

[ 外观性状 ]:
固体;Dark green to Dark red to Black powder to crystal

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：可溶；微溶：乙醇

食品黑1MSDS

详细MSDS(安全技术说明书)

食品黑1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5950000

CHEMICAL NAME :: 1,7-Naphthalenedisulfonic acid, 4-acetamido-5-hydroxy-6-((7-sulfo-4-((p-sulfophenyl)a zo)- 1-naphthyl)azo)-, tetrasodium salt

CAS REGISTRY NUMBER :: 2519-30-4

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C28-H21-N5-O14-S4.4Na

MOLECULAR WEIGHT :: 871.74

WISWESSER LINE NOTATION :: L66J BQ DSWQ GSWQ JMV1 CNUN- EL66J BNUNR DSWQ& HSWQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 7,557,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,402,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 162 gm/kg/90D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1543 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2422 (estimated) No. of Female Employees: 384 (estimated)

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食品黑1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QJ5950000

食品黑1文献

A novel optical approach to achieving tooth whitening.

J. Dent. 36 Suppl 1 , S8-14, (2008)

To investigate a new optical approach to tooth whitening by enhancing the measurement and perception of tooth whiteness using blue coloured materials deposited onto the tooth surface.Salivary pellicle...

The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151).

Cell Mol. Biol. Lett. 9(1) , 107-22, (2004)

Additives, especially colors, are in widespread use in the food industry. With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite rep...

Liquid chromatographic quantification of synthetic colorants in fish roe and caviar. Kirschbaum, Jochen, Corina Krause, and Hans Brückner

Eur. Food Res. Technol. 222.5-6 , 572-579, (2006)

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