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4-苯基-2-丁酮

4-苯基-2-丁酮用途

Benzylacetone 是从沉香木中提取的芳香族化合物。Benzylacetone 具有较强且可逆的抗蘑菇酪氨酸酶活性,对单酚酶和双酚酶作用的 IC50 值分别为 2.8 mM 和 0.6 mM。Benzylacetone 具有增强食欲和减少运动的作用。
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4-苯基-2-丁酮名称

[ CAS 号 ]:
2550-26-7

[ 中文名 ]:
苄基丙酮

[ 英文名 ]:
Benzylacetone

[中文别名 ]:

[英文别名 ]:

4-苯基-2-丁酮生物活性

[ 描述 ]:

Benzylacetone 是从沉香木中提取的芳香族化合物。Benzylacetone 具有较强且可逆的抗蘑菇酪氨酸酶活性,对单酚酶和双酚酶作用的 IC50 值分别为 2.8 mM 和 0.6 mM。Benzylacetone 具有增强食欲和减少运动的作用。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶
研究领域 >> 代谢疾病

[ 靶点 ]

IC50: 2.8 mM (monophenolase, tyrosinase mushroom), 0.6 mM (diphenolase, tyrosinase mushroom)[2]


[参考文献]

[1]. Takamatsu S, et al. Agarotetrol: a source compound for low molecular weight aromatic compounds from agarwood heating. J Nat Med. 2018 Mar;72(2):537-541.

[2]. Liu X, et al. Inhibition effects of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol on the activity of mushroom tyrosinase. J Biosci Bioeng. 2015 Mar;119(3):275-9.

[3]. Ogawa K, et al. Appetite-Enhancing Effects: The Influence of Concentrations of Benzylacetone and trans-Cinnamaldehyde and Their Inhalation Time, as Well as the Effect of Aroma, on Body Weight in Mice. Biol Pharm Bull. 2016;39(5):794-8.

4-苯基-2-丁酮物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
233.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-13ºC

[ 分子式 ]:
C10H12O

[ 分子量 ]:
148.202

[ 闪点 ]:
98.3±0.0 °C

[ 精确质量 ]:
148.088821

[ PSA ]:
17.07000

[ LogP ]:
1.67

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.504

[ 储存条件 ]:
室温

[ 水溶解性 ]:
PRACTICALLY INSOLUBLE

4-苯基-2-丁酮MSDS

4-苯基-2-丁酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL9600000
CHEMICAL NAME :
2-Butanone, 4-phenyl-
CAS REGISTRY NUMBER :
2550-26-7
BEILSTEIN REFERENCE NO. :
1907123
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H12-O
MOLECULAR WEIGHT :
148.22
WISWESSER LINE NOTATION :
1V2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,647,1983
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,647,1983 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,647,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(5),7,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
583 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(5),7,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,647,1983
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4-苯基-2-丁酮安全信息

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R38

[ 安全声明 (欧洲) ]:
S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
EL9600000

[ 海关编码 ]:
29143900

4-苯基-2-丁酮上下游产品

4-苯基-2-丁酮制备

1.由氯苄经缩合、水解、脱二氧化碳而得。(2)由苯甲醛和丙酮合成苄叉丙酮,再经氢化还原得4-苯基丁酮-2。4-苯基丁酮-2的制备将乙醇(95%1100ml)、苄叉丙酮(480g)、Raney Ni(48g)、适量乙酸投入反应瓶,将温度控制在48-50℃,常压搅拌吸氢至足量。反应4-5h。滤去Raney Ni。滤液蒸去乙醇,减压蒸馏,收集123-125℃(2.67kPa)馏分,得4-苯基丁酮-2为465.8g。折光率1.513,收率95.7%。

2.制法:

参照苯基丙酮的制备方法,用苯丙酸(2)100g(0.66mol)、冰醋酸160g(2.66mol)进行反应,用乙醚提取后蒸馏,收集230~235℃的馏分,得4-苯基-2-丁酮(1)70g,收率71%。纯的4-苯基-2-丁酮bp234℃。

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4-苯基-2-丁酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

4-苯基-2-丁酮文献

Online capillary solid-phase microextraction coupled liquid chromatography-mass spectrometry for analysis of chiral secondary alcohol products in yeast catalyzed stereoselective reduction cell culture.

J. Chromatogr. A. 1380 , 1-10, (2015)

An online solid-phase microextraction coupled liquid chromatography-electrospray ionization-ion trap mass spectrometry was developed for the analysis of trace R- and S-4-phenyl-2-butanol (R- and S-pbo...

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp.

PLoS ONE 6(1) , e16084, (2011)

Many bacteria, including Vibrio spp., regulate virulence gene expression in a cell-density dependent way through a communication process termed quorum sensing (QS). Hence, interfering with QS could be...


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¥58.0/50ml ¥180.0/250ml ¥643.0/1l ¥2592.0/5l

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价格:
¥81.9/100ml ¥30.9/25ml ¥371.9/1l ¥124.9/250ml

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产品详情:苄基丙酮


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【4-苯基-2-丁酮】化源网提供4-苯基-2-丁酮CAS号2550-26-7,4-苯基-2-丁酮MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询4-苯基-2-丁酮上化源网,专业又轻松。>>电脑版:4-苯基-2-丁酮

标题:4-苯基-2-丁酮_MSDS_用途_密度_CAS号【2550-26-7】_化源网 地址:https://m.chemsrc.com/mip/cas/2550-26-7_751784.html