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N,2-二甲基-丙氨酸

N,2-二甲基-丙氨酸用途

α-(甲氨基)异丁酸是氨基酸转运系统a(ATA1)的特异性底物。ATA以Na+依赖的方式介导短链中性氨基酸的摄取[1]。

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N,2-二甲基-丙氨酸名称

[ CAS 号 ]:
2566-34-9

[ 中文名 ]:
2-(甲氨基)异丁酸水合物

[ 英文名 ]:
N,2-Dimethylalanine

[中文别名 ]:

[英文别名 ]:

N-Methyl-a-aminoisobutyric acid
N,2-Dimethylalanine
2 methylaminoisobutyrate
MFCD00004191
2,N-Dimethylalanine
N,2-Dimethylalanine Hydrate
2-(MethylaMino)isobutyric Acid Hydrate
Alanine, N,2-dimethyl-
2-(Methylamino)-2-methylpropionic acid
2-Methylaminoisobutyric acid

N,2-二甲基-丙氨酸生物活性

[ 描述 ]:

α-(甲氨基)异丁酸是氨基酸转运系统a(ATA1)的特异性底物。ATA以Na+依赖的方式介导短链中性氨基酸的摄取[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

ATA3是氨基酸转运系统a的一个新亚型,主要表达于肝脏和骨骼肌。ATA1(也称为GlnT)和ATA2(也称为SAT2)已从大鼠和人类组织中克隆。这些转运体以Na+依赖的方式介导短链中性氨基酸的摄取[1]。

[参考文献]

[1]. M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13.

[2]. Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41.

N,2-二甲基-丙氨酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
192.5±23.0 °C at 760 mmHg

[ 熔点 ]:
> 300ºC

[ 分子式 ]:
C₅H₁₁NO₂

[ 分子量 ]:
117.146

[ 闪点 ]:
70.2±22.6 °C

[ 精确质量 ]:
117.078979

[ PSA ]:
49.33000

[ LogP ]:
-0.10

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C

[ 折射率 ]:
1.442

[ 储存条件 ]:
−20°C

N,2-二甲基-丙氨酸MSDS

N,2-二甲基-丙氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

N,2-二甲基-丙氨酸合成路线

N,2-二甲基-丙氨酸上下游产品

N,2-二甲基-丙氨酸上游产品

N,2-二甲基-丙氨酸下游产品

N,2-二甲基-丙氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

N,2-二甲基-丙氨酸文献

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells.

Anticancer Res. 23 , 1245-1248, (2003)

A single hepatoma cell line was grown in vitro and incubated with L-2,4 diaminobutyric acid (DAB), a non-metabolizable amino acid, under various conditions. The tumour cells were irreversibly damaged ...

Integrin participates in the effect of thyroxine on plasma membrane in immature rat testis.

Biochim. Biophys. Acta 1830(3) , 2629-37, (2013)

The secretory activity of Sertoli cells (SC) is dependent on ion channel functions and protein synthesis and is critical to ongoing spermatogenesis. The aim of this study was to investigate the mechan...

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