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盐酸氯苯胍

盐酸氯苯胍用途

罗伯尼丁是一种抗球虫剂,可用于研究由艾美耳属寄生虫引起的球虫病[1]。

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盐酸氯苯胍名称

[ CAS 号 ]:
25875-51-8

[ 中文名 ]:
罗贝胍

[ 英文名 ]:
Robenidine hydrochloride

[中文别名 ]:

[英文别名 ]:

Khimcoccid
Chimcoccide
Khimkoktsid
Robenidine
Khimkoktside
Robenidine hydrochloride
EINECS 247-308-3

盐酸氯苯胍生物活性

[ 描述 ]:

罗伯尼丁是一种抗球虫剂,可用于研究由艾美耳属寄生虫引起的球虫病[1]。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Krollenbrock A, et, al. Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum. ACS Infect Dis. 2021 Jul 9;7(7):1956-1968.

盐酸氯苯胍物理化学性质

[ 密度 ]:
1.33 g/cm3

[ 沸点 ]:
488.1ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₃Cl₂N₅

[ 分子量 ]:
334.20

[ 闪点 ]:
249ºC

[ 精确质量 ]:
333.05500

[ PSA ]:
72.63000

[ LogP ]:
4.35690

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.634

[ 储存条件 ]:
室温

盐酸氯苯胍毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ME8650000

CHEMICAL NAME :: Guanidine, 1,3-bis((p-chlorobenzylidene)amino)-

CAS REGISTRY NUMBER :: 25875-51-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H13-Cl2-N5

MOLECULAR WEIGHT :: 334.23

WISWESSER LINE NOTATION :: GR D1 UNMYUM&MNU1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 53(11),69,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1017 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981