D-苏式-鞘胺醇-1-磷酸

D-苏式-鞘胺醇-1-磷酸用途

Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使,动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。

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D-苏式-鞘胺醇-1-磷酸名称

[ CAS 号 ]:
26993-30-6

[ 中文名 ]:
D-苏式-鞘胺醇-1-磷酸

[ 英文名 ]:
Sphingosine-1-phosphate

[中文别名 ]:

D-赤型神经胺磷酸盐

[英文别名 ]:

Sphing-4-enine 1-phosphate
C18-Sphingosine 1-phosphate
D-erythro-sphingosine-1-phosphate
Sphingosine 1-phosphate
MFCD00274457
S1P
Sphingosine 1-phosphic acid
D-erythro-Sphingosine 1-phosphate
Somatostatin 1-28

D-苏式-鞘胺醇-1-磷酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

在血清饥饿条件下(1%FCS),S1P(1μM)诱导HEK293细胞产生显著的Ca2+释放[1]。在功能性Ca2+测定中,单独使用苏拉明(HY-B0879)不通过gpr3、gpr6或gpr12对细胞内Ca2+释放产生任何影响。相比之下,在转染的HEK293细胞中,在不同浓度的苏拉明(HY-B0879)存在下,S1P(1μM)诱导gpr3、gpr6和gpr12的Ca2+释放[2]。在功能性Ca2+分析中,在苏拉明(300μM)存在下,S1P(3-3000 nM)分别在HEK293细胞中显示gpr3(EC50=29 nM)、gpr6(EC50=15 nM)和gpr12(EC50=24 nM)、大鼠gpr3(EC50=68 nM)的纳摩尔EC50值[2]。S1P增加表达S1P1和Gqi5的TAg Jurkat细胞中的细胞内钙水平,当浓度为200 nM时,允许Gi蛋白质刺激磷脂酶C,以及表达S1P2和S1P3受体的TAg Jurkat细胞(EC50s分别为8和11nM)[3]。

[参考文献]

[1]. Teresa Sanchez, et al. Structural and Functional Characteristics of S1P Receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22.

[2]. Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal. 2002 Nov;14(11):941-53.

[3]. S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94

D-苏式-鞘胺醇-1-磷酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
548.8±60.0 °C at 760 mmHg

[ 熔点 ]:
190ºC

[ 分子式 ]:
C₁₈H₃₈NO₅P

[ 分子量 ]:
379.472

[ 闪点 ]:
285.7±32.9 °C

[ 精确质量 ]:
379.248749

[ PSA ]:
122.82000

[ LogP ]:
5.46

[ 外观性状 ]:
灰白色至灰色粉末

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.501

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Moisture, Temperature Sensitive; Hygroscopic

[ 水溶解性 ]:
methanol: THF: water (6:3:1): >0.5 mg/mL

D-苏式-鞘胺醇-1-磷酸MSDS

详细MSDS(安全技术说明书)

D-苏式-鞘胺醇-1-磷酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

D-苏式-鞘胺醇-1-磷酸合成路线

详细合成路线

D-苏式-鞘胺醇-1-磷酸上下游产品

D-苏式-鞘胺醇-1-磷酸上游产品

D-苏式-鞘胺醇-1-磷酸下游产品

D-苏式-鞘胺醇-1-磷酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

D-苏式-鞘胺醇-1-磷酸文献

The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.

Biochem. Biophys. Res. Commun. 463 , 545-50, (2015)

In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide...

Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.

Biochim. Biophys. Acta 1841(6) , 836-46, (2014)

Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive mo...

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

Development 141(23) , 4513-25, (2014)

Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essen...

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