6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl-

用途

9-(β-D-呋喃甲酰基)鸟嘌呤是一种鸟苷类似物。一些鸟苷类似物具有免疫刺激活性。在一些动物模型中,它们还诱导I型干扰素,产生抗病毒作用。研究表明,鸟苷类似物的功能活性取决于Toll样受体7(TLR7)的激活[1]。

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名称

[ CAS 号 ]:
27462-39-1

[ 英文名 ]:
6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl-

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

物理化学性质

[ 分子式 ]:
C₁₀H₁₃N₅O₅

[ 分子量 ]:
283.24

[ 精确质量 ]:
283.09200

[ PSA ]:
159.51000

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8610000

CHEMICAL NAME :: Guanine, 9-(beta-D-xylofuranosyl)-

CAS REGISTRY NUMBER :: 27462-39-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FVM INJ HZ B1- BT5OTJ CQ DQ EQ -D,BETA,XYLO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,203,1986