7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮
名称
[ CAS 号 ]:
2886-65-9
[ 中文名 ]:
7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮
[ 英文名 ]:
N-Desalkylflurazepam
[中文别名 ]:
[英文别名 ]:
- Norfludiazepam
- N-Desalkylflurazepam
- Ro 5-3367
- Norflutoprazepam
- EINECS 220-748-3
- Dealkylflurazepam
- nor-Flurazepam
- MFCD00083443
- CM 7116
- N-DESALKYL-2-OXOQUAZEPAM
物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
463.5±55.0 °C at 760 mmHg
[ 熔点 ]:
204-206°C
[ 分子式 ]:
C15H10ClFN2O
[ 分子量 ]:
288.704
[ 闪点 ]:
234.1±31.5 °C
[ 精确质量 ]:
288.046570
[ PSA ]:
41.46000
[ LogP ]:
2.40
[ 外观性状 ]:
淡黄色固体
[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C
[ 折射率 ]:
1.648
[ 储存条件 ]:
-20°C Freezer
MSDS
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF2370100
- CHEMICAL NAME :
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-
- CAS REGISTRY NUMBER :
- 2886-65-9
- BEILSTEIN REFERENCE NO. :
- 0754061
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H10-Cl-F-N2-O
- MOLECULAR WEIGHT :
- 288.72
- WISWESSER LINE NOTATION :
- T67 GMV JN IHJ CG KR BF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973 Volume(issue)/page/year: -,46,1973
安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
F,T
[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25
[ 安全声明 (欧洲) ]:
S22-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
DF2370100
[ 海关编码 ]:
2933990090
合成路线
上下游产品
上游产品
下游产品
海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
文献
Xenobiotica 44(10) , 893-901, (2014)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydra...
Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).Forensic Sci. Int. 243 , 99-106, (2014)
The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-res...
Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)
• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥1667.0/50mg
联系人:李先生
产品详情:N-Desalkylflurazepam
公司名:盼得(上海)国际贸易有限公司
区域:上海市徐汇区
价格:
¥需询单/500g
¥需询单/1kg
¥需询单/25kg
¥需询单/200kg
联系人:叶经理
产品详情:7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮
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