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7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮

名称

[ CAS 号 ]:
2886-65-9

[ 中文名 ]:
7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮

[ 英文名 ]:
N-Desalkylflurazepam

[中文别名 ]:

[英文别名 ]:

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
463.5±55.0 °C at 760 mmHg

[ 熔点 ]:
204-206°C

[ 分子式 ]:
C15H10ClFN2O

[ 分子量 ]:
288.704

[ 闪点 ]:
234.1±31.5 °C

[ 精确质量 ]:
288.046570

[ PSA ]:
41.46000

[ LogP ]:
2.40

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
-20°C Freezer

MSDS

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF2370100
CHEMICAL NAME :
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-
CAS REGISTRY NUMBER :
2886-65-9
BEILSTEIN REFERENCE NO. :
0754061
LAST UPDATED :
199706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H10-Cl-F-N2-O
MOLECULAR WEIGHT :
288.72
WISWESSER LINE NOTATION :
T67 GMV JN IHJ CG KR BF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973 Volume(issue)/page/year: -,46,1973
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安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DF2370100

[ 海关编码 ]:
2933990090

合成路线

上下游产品

海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.

Xenobiotica 44(10) , 893-901, (2014)

1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydra...

Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).

Forensic Sci. Int. 243 , 99-106, (2014)

The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-res...

Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)

• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.


更多文献

推荐生产厂家/供应商:

公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥1667.0/50mg

联系人:李先生

产品详情:N-Desalkylflurazepam


公司名:上海创赛科技有限公司

区域:上海市嘉定区

价格:
¥200.0/1g

联系人:夏言

产品详情:[Perfemiker]7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮,≥98%


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标题:2886-65-9_CAS号:2886-65-9_7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮 - 化源网 地址:https://m.chemsrc.com/mip/cas/2886-65-9_583413.html