硒代-DL-胱氨酸

硒代-DL-胱氨酸用途

Selenocystine 是一种广谱抗癌剂。Selenocystine 诱导 HepG2 细胞的 DNA 损伤,特别是 DNA双链断裂 (DSBs)。Selenocystine 有潜力用于在癌症治疗中作为靶向 DNA 修复的治疗或辅助剂具有很大的前景。

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硒代-DL-胱氨酸名称

[ CAS 号 ]:
2897-21-4

[ 中文名 ]:
硒代-DL-胱氨酸

[ 英文名 ]:
Seleno-DL-cystine

[英文别名 ]:

seleno-dl-cystine
alanine,3,3'-diselenobis-

硒代-DL-胱氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[ 靶点 ]

IC50: Anti-cancer[1]

[参考文献]

[1]. Eva Ari Wahyuni, et al. Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells. Chem Biol Interact. 2022 Sep 25:365:110046.

硒代-DL-胱氨酸物理化学性质

[ 分子式 ]:
C₆H₁₂N₂O₄Se₂

[ 分子量 ]:
334.09

[ 精确质量 ]:
335.91300

[ PSA ]:
126.64000

[ 蒸汽压 ]:
5.12E-13mmHg at 25°C

[ 储存条件 ]:
-20°C

硒代-DL-胱氨酸安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H373-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
23/25-33-50/53

[ 安全声明 (欧洲) ]:
20/21-28-45-60-61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3.0

[ RTECS号 ]:
AY6031000

[ 海关编码 ]:
2922499990

硒代-DL-胱氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

硒代-DL-胱氨酸文献

Bioaccessibility of selenium, selenomethionine and selenocysteine from foods and influence of heat processing on the same.

Food Chem. 194 , 1293-9, (2015)

Selenium (Se) is an essential nutrient with diverse physiological functions. The selenium content of commonly consumed cereals, pulses and green leafy vegetables (GLV) was determined. Bioaccessibility...

Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.).

Environ. Toxicol. Chem. 32(11) , 2584-92, (2013)

Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because...

Selenocystine induces reactive oxygen species–mediated apoptosis in human cancer cells

Biomed. Pharmacother. 63(2) , 105-13, (2009)

Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally availabl...

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