苯他西泮
苯他西泮用途
苯他西泮(噻吩)是一种具有短效抗焦虑作用的化合物。苯他西泮具有抗惊厥和镇静作用。苯他西泮可用于抑郁症和焦虑症的研究[1]。
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苯他西泮名称
[ CAS 号 ]:
29462-18-8
[ 中文名 ]:
苯他西泮
[ 英文名 ]:
Bentazepam
[英文别名 ]:
- Bentazepam
- CI-718
- Tiadipone
- Thiadipone
- QM-6008
- Bentazepamum [INN-Latin]
苯他西泮生物活性
苯他西泮物理化学性质
[ 密度 ]:
1.38g/cm3
[ 沸点 ]:
532.6ºC at 760 mmHg
[ 分子式 ]:
C17H16N2OS
[ 分子量 ]:
296.38700
[ 闪点 ]:
275.9ºC
[ 精确质量 ]:
296.09800
[ PSA ]:
69.70000
[ LogP ]:
2.99000
[ 蒸汽压 ]:
2E-11mmHg at 25°C
[ 折射率 ]:
1.733
[ 储存条件 ]:
通风低温干燥
苯他西泮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DL8230000
- CHEMICAL NAME :
- 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-
- CAS REGISTRY NUMBER :
- 29462-18-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H16-N2-O-S
- MOLECULAR WEIGHT :
- 296.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 129 mg/kg/17W-I
- TOXIC EFFECTS :
- Behavioral - anorexia (human) Behavioral - muscle weakness Liver - liver function tests impaired
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,860,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 980 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 630 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
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苯他西泮合成路线
苯他西泮上下游产品
苯他西泮上游产品
苯他西泮下游产品
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