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2,2'-偶氮双(2-甲基丙脒)二盐酸盐

2,2'-偶氮双(2-甲基丙脒)二盐酸盐用途

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) 具有自由基生成作用。AAPH 诱导氧化应激和红细胞溶血。

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2,2'-偶氮双(2-甲基丙脒)二盐酸盐名称

[ CAS 号 ]:
2997-92-4

[ 中文名 ]:
2,2'-偶氮二异丁基脒二盐酸盐

[ 英文名 ]:
2,2'-Azobis(2-methylpropionamidine) dihydrochloride

[中文别名 ]:

[英文别名 ]:

2,2-AZOBIS-(2-AMIDINOPROPANE) HCL
AAPH
Azostarter V 50
ms1
ABAP
2,2-Azobis(2-Methylpropionamidine) Dihydrochloride
ms1(catalyst)
v50
2,2'-Azobis(2
2,2′-azobis(isobutyramidine) dihydrochloride

2,2'-偶氮双(2-甲基丙脒)二盐酸盐生物活性

[ 描述 ]:

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) 具有自由基生成作用。AAPH 诱导氧化应激和红细胞溶血。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038.

[2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54.

2,2'-偶氮双(2-甲基丙脒)二盐酸盐物理化学性质

[ 密度 ]:
0.42

[ 沸点 ]:
267ºC at 760 mmHg

[ 熔点 ]:
160-169 ºC

[ 分子式 ]:
C₈H₂₀Cl₂N₆

[ 分子量 ]:
271.191

[ 闪点 ]:
115.3ºC

[ 精确质量 ]:
270.112640

[ PSA ]:
124.46000

[ LogP ]:
4.07180

[ 外观性状 ]:
白色至灰白色颗粒

[ 蒸汽压 ]:
8.02E-05mmHg at 25°C

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 稳定性 ]:
Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids.

[ 水溶解性 ]:
acetone, dioxane, methanol, ethanol, DMSO and water: soluble

2,2'-偶氮双(2-甲基丙脒)二盐酸盐MSDS

详细MSDS(安全技术说明书)

2,2'-偶氮双(2-甲基丙脒)二盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE4575500

CHEMICAL NAME :: Propionamidine, 2,2'-azobis(2-methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 2997-92-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H18-N6.2Cl-H

MOLECULAR WEIGHT :: 271.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

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2,2'-偶氮双(2-甲基丙脒)二盐酸盐安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H242-H302-H317

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R43

[ 安全声明 (欧洲) ]:
S24-S37

[ 危险品运输编码 ]:
UN 3226 4.1

[ WGK德国 ]:
1

[ RTECS号 ]:
UE4575500

[ 包装等级 ]:
III

[ 危险类别 ]:
5.1

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