马兜铃酸A

马兜铃酸A用途

Aristolochic acid A (Aristolochic acid I) 是植物提取物 Aristolochic acids 的主要成分,其存在于 Aristolochia 和 Asarum 草本植物中。Aristolochic acid A 显着降低激活蛋白1 (AP-1) 和 NF-κB 活性。Aristolochic acid A 降低人细胞中膀胱癌相关 BLCAP 基因表达。

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马兜铃酸A名称

[ CAS 号 ]:
313-67-7

[ 中文名 ]:
马兜铃酸

[ 英文名 ]:
Aristolochic acid A

[中文别名 ]:

[英文别名 ]:

Aristolohic Acid A
Descresept
Aristolochic acid
birthwort
AristolochicacidI
EINECS 206-238-3
Aristolochia
tardolyt
Aristolochic Acid A
Aristolochia A

马兜铃酸A生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

[体外研究]

马兜铃酸A(150,200μM,24小时)抑制肾细胞HEK293和HK-2的细胞活力[1]。马兜铃酸A(100,200μM,24小时)引起肾细胞(HEK 293和HK-2)和膀胱癌细胞系(HT-1376)中膀胱癌相关蛋白(BLCAP)mRNA水平的浓度依赖性降低。 )[1]。马兜铃酸A(100,200μM,24小时)在HEK293和HT-1376细胞中以剂量依赖性方式削弱BLCAP蛋白信号[1]。细胞活力测定[1]细胞系：肾细胞(HEK 293和HK-2)浓度：50,100,150,200μM孵育时间：24小时结果：HEK293和HK-2的细胞活力低于细胞活力载体处理的培养物直至150μM和200μM。 RT-PCR [1]细胞系：肾细胞(HEK 293和HK-2)和膀胱癌细胞系(HT-1376)浓度：100,200μM孵育时间：24小时结果：下调BLCAP mRNA水平。蛋白质印迹分析[1]细胞系：HEK293和HT-1376细胞浓度：100,200μM孵育时间：24小时结果：以剂量依赖性方式降低BLCAP蛋白表达。

[参考文献]

[1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.

马兜铃酸A物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
615.5±55.0 °C at 760 mmHg

[ 熔点 ]:
260 °C

[ 分子式 ]:
C₁₇H₁₁NO₇

[ 分子量 ]:
341.27

[ 闪点 ]:
326.0±31.5 °C

[ 精确质量 ]:
341.053558

[ PSA ]:
110.81000

[ LogP ]:
3.41

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.747

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
DMSO: soluble

马兜铃酸AMSDS

详细MSDS(安全技术说明书)

马兜铃酸A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF3325000

CHEMICAL NAME :: Aristolochine

CAS REGISTRY NUMBER :: 313-67-7

BEILSTEIN REFERENCE NO. :: 0345159

LAST UPDATED :: 199612

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C17-H11-N-O7

MOLECULAR WEIGHT :: 341.29

WISWESSER LINE NOTATION :: T C5 B666 DO FO EHJ IVQ KNW NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 3 mg/kg/2D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55900 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14320 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38400 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg/11D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg/3W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Mutation in mammalian somatic cells

TYPE OF TEST :: Mutation in mammalian somatic cells

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,447,1988

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马兜铃酸A安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S7-S35-S45

[ 危险品运输编码 ]:
UN 1544 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
CF3325000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

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马兜铃酸A文献

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.

Toxicology 318 , 22-31, (2014)

Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This study aimed to investigate the role ...

Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.

Int. J. Mol. Sci. 16 , 16454-68, (2015)

Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was co...

Association of blood lead and mercury with estimated GFR in herbalists after the ban of herbs containing aristolochic acids in Taiwan.

Occup. Environ. Med. 70(8) , 545-51, (2013)

This study was undertaken to explore the association of estimated glomerular filtration rate (GFR) with exposure to aristolochic acids (ALAs) and nephrotoxic metals in herbalists after the ban of herb...

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