5-氯代水杨酸

【用途一】
用作农药、医药、染料中间体
【用途二】
染料、医药的中间体。

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
320.5±27.0 °C at 760 mmHg

[ 熔点 ]:
171-172 °C(lit.)

[ 分子式 ]:
C₇H₅ClO₃

[ 分子量 ]:
172.566

[ 闪点 ]:
147.6±23.7 °C

[ 精确质量 ]:
171.992722

[ PSA ]:
57.53000

[ LogP ]:
3.42

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
室温

[ 水溶解性 ]:
1 g/L (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

VO2080000

CHEMICAL NAME :

Salicylic acid, 5-chloro-

CAS REGISTRY NUMBER :

321-14-2

BEILSTEIN REFERENCE NO. :

2046665

LAST UPDATED :

199709

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C7-H5-Cl-O3

MOLECULAR WEIGHT :

172.57

WISWESSER LINE NOTATION :

QVR BQ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,792,1955 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

80 mg/kg/4D-I

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 52,454,1980

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
VO2080000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29182990

详细合成路线

5-氯代水杨酸上游产品

5-氯代水杨酸下游产品

将氯苯加入搪瓷锅蒸去水分至0.03%以下，投入水杨酸，在110± 2 ℃ 均匀通氯至预定量。取样观察 冷至 30 ℃ 的析出物，过滤，测熔点，以167 -175 ℃ 为合格，即得5-氯水杨酸的氯苯溶液。如果氯化反应在日光灯照射下进行，则在55 -80 ℃ 能氯至理论量，取样检测合格后，排除剩余氯，冷却，过滤，用氯苯洗涤，干燥，即得成品。

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

J. Med. Chem. 48 , 2469-79, (2005)

A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities. These CXCL8 inhibitors are derivatives of phe...

Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.

Eur. J. Med. Chem. 48 , 36-44, (2012)

To develop a more potent NFκB inhibitor from salicylic acid which is known to inhibit activity of NFκB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, de...

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

Bioorg. Med. Chem. 16 , 9101-5, (2008)

The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and II, with a series of salicylic acid derivatives was investigated by using the esterase method with 4-nitr...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：5-氯水杨酸

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公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：5-氯水杨酸

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥108.0/100g ￥348.0/500g

联系人：刘佳

产品详情：5-氯水杨酸

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥101.0/100g ￥351.0/500g ￥1564.0/2500g

联系人：夏言

产品详情：[Perfemiker]5-氯水杨酸,99%

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥93.9/100g ￥29.9/25g ￥768.9/3kg ￥120.9/250g

联系人：阿拉丁

产品详情：5-氯水杨酸

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