< 生产厂家价格 >

1-氟萘

1-氟萘用途

1-氟萘是一种有机氟化合物,衍生自萘衍生物和氟化芳烃。1-氟萘可用于合成LY248686,一种有效的5-羟色胺和去甲肾上腺素摄取抑制剂[1]。

点击显示

1-氟萘名称

[ CAS 号 ]:
321-38-0

[ 中文名 ]:
1-氟萘

[ 英文名 ]:
1-Fluoronaphthalene

[中文别名 ]:

[英文别名 ]:

1-FLUORONAPTHALENE
α-Fluoronaphthalene
1-fluoromaphthalene
1-fluoro-naphthalen
Naphthalene, 1-fluoro-
EINECS 206-287-0
1-Fluornaphthalen
4-fluoro-l-naphthalene
I-Fluoronaphthalene
1-Flouronaphthalene

1-氟萘生物活性

[ 描述 ]:

1-氟萘是一种有机氟化合物,衍生自萘衍生物和氟化芳烃。1-氟萘可用于合成LY248686,一种有效的5-羟色胺和去甲肾上腺素摄取抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

1-氟萘(3 mg,24 h)可被秀丽线虫ATCC 36112氧化,形成反式-3,4-二羟基-3,4-双氢-1-氟萘和反式-5,6-二羟基-5,6-双氢-1--氟萘,并形成1-氟-8-羟基-5-四酮、5-羟基-1-氟代萘和4-羟基-1-氟代萘以及这些酚的葡糖苷、硫酸盐和葡糖醛酸缀合物[1]。

[参考文献]

[1]. C E Cerniglia, et al. Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene. Appl Environ Microbiol. 1984 Aug;48(2):294-300.

1-氟萘物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
215.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−13 °C(lit.)

[ 分子式 ]:
C₁₀H₇F

[ 分子量 ]:
146.161

[ 闪点 ]:
65.6±0.0 °C

[ 精确质量 ]:
146.053177

[ LogP ]:
3.50

[ 外观性状 ]:
针状

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.606

[ 储存条件 ]:
室温，易燃物区域

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
可溶于：醇,苯

1-氟萘MSDS

详细MSDS(安全技术说明书)

1-氟萘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ7100000

CHEMICAL NAME :: Naphthalene, 1-fluoro-

CAS REGISTRY NUMBER :: 321-38-0

BEILSTEIN REFERENCE NO. :: 1906413

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H7-F

MOLECULAR WEIGHT :: 146.17

WISWESSER LINE NOTATION :: L66J BF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 22,1133,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4416 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

点击显示

1-氟萘安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37-S24/25-S23-S53

[ 危险品运输编码 ]:
UN 2810

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ7100000

[ 海关编码 ]:
2903999090

1-氟萘上下游产品

1-氟萘上游产品

1-氟萘下游产品

1-氟萘海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

1-氟萘文献

Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base.

Org. Lett. 5(7) , 1155-8, (2003)

[reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) ...

Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene.

Appl. Environ. Microbiol. 48(2) , 294-300, (1984)

The metabolism of 1-fluoronaphthalene by Cunninghamella elegans ATCC 36112 was studied. The metabolites were isolated by reverse-phase high-pressure liquid chromatography and characterized by the appl...

A one-pot access to 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes.

Org. Lett. 4(16) , 2687-90, (2002)

[reaction: see text] A one-pot, t-BuLi-induced synthesis of 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes is reported. Aryl- and hetaryl nitriles, cyanamides, and trimeth...

更多文献