1,4-丁二胺双盐酸盐

1,4-丁二胺双盐酸盐用途

1,4-Diaminobutane dihydrochloride 是一种内源性代谢物,能作为高等植物大麦和油菜受 Cr (III) 或 Cr (VI) 胁迫引起污染的指标。1,4-Diaminobutane dihydrochloride 是 GABA 的重要来源。

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1,4-丁二胺双盐酸盐名称

[ CAS 号 ]:
333-93-7

[ 中文名 ]:
1,4-丁二胺二盐酸盐

[ 英文名 ]:
butane-1,4-diaminium dichloride

[中文别名 ]:

[英文别名 ]:

1,4-DIAMINOBUTANE 2HCL
1,4-BUTANEDIAMMONIUM DICHLORIDE
Putrescin dihydrochloride
TETRAMETHYLENEDIAMINE 2HCL
EINECS 206-375-9
butane-1,4-diamine dihydrochloride
PUTRESCINE HYDROCHLORIDE
Putrescine 2HCl
1,4-Butanediamine, hydrochloride (1:2)
DIAMINOBUTANE DIHYDROCHLORIDE

1,4-丁二胺双盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite[1]

[体外研究]

1,4-二氨基丁烷是出生后大鼠心室下区GABA的重要来源。从替代途径合成GABA使用1,4-丁二胺作为前体[2]。

[参考文献]

[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.

[2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.

1,4-丁二胺双盐酸盐物理化学性质

[ 密度 ]:
1.472g/cm3

[ 沸点 ]:
159ºC at 760 mmHg

[ 熔点 ]:
280 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₁₄Cl₂N₂

[ 分子量 ]:
161.073

[ 闪点 ]:
51.7ºC

[ 精确质量 ]:
160.053406

[ PSA ]:
52.04000

[ LogP ]:
2.68860

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but hygroscopic. Substances to be avoided: strong oxidizing agents. Combustible.

[ 水溶解性 ]:
H2O: 100 mg/mL

1,4-丁二胺双盐酸盐MSDS

1,4-丁二胺双盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7280000

CHEMICAL NAME :: 1,4-Butanediamine, dihydrochloride

CAS REGISTRY NUMBER :: 333-93-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H12-N2.2Cl-H

MOLECULAR WEIGHT :: 161.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1880 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 2 mmol/L

REFERENCE :: JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 78,217,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1000 No. of Facilities: 81 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 236 (estimated)

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1,4-丁二胺双盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EJ7280000

[ 海关编码 ]:
2921290000

1,4-丁二胺双盐酸盐合成路线

1,4-丁二胺双盐酸盐上下游产品

1,4-丁二胺双盐酸盐上游产品

1,4-丁二胺双盐酸盐下游产品

1,4-丁二胺双盐酸盐制备

由吡咯与盐酸羟胺反应得到丁二肟，再经还原而得丁二胺。

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1,4-丁二胺双盐酸盐海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

1,4-丁二胺双盐酸盐文献

pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity.

Biomaterials 55 , 33-43, (2015)

At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells u...

Tritiation and characterization of several polyamine natural products.

Appl. Radiat. Isot. 98 , 71-3, (2015)

Effect of Novel Starter Culture on Reduction of Biogenic Amines, Quality Improvement, and Sensory Properties of Doenjang, a Traditional Korean Soybean Fermented Sauce Variety.

J. Food Sci. 80 , M1794-803, (2015)

To select appropriate microorganisms as starter cultures for the reliable and reproducible fermentation of soybean fermented products of Korean Doenjang, various ratios of fungi (Aspergillus oryzae J,...

更多文献

1,4-丁二胺双盐酸盐

1,4-丁二胺双盐酸盐用途

1,4-丁二胺双盐酸盐名称

1,4-丁二胺双盐酸盐生物活性

1,4-丁二胺双盐酸盐物理化学性质

1,4-丁二胺双盐酸盐MSDS

详细MSDS(安全技术说明书)

1,4-丁二胺双盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,4-丁二胺双盐酸盐安全信息

1,4-丁二胺双盐酸盐合成路线

详细合成路线

1,4-丁二胺双盐酸盐上下游产品

1,4-丁二胺双盐酸盐上游产品

1,4-丁二胺双盐酸盐下游产品

1,4-丁二胺双盐酸盐制备

1,4-丁二胺双盐酸盐海关

1,4-丁二胺双盐酸盐文献

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