N-(叔丁氧羰基)-1,4-丁二胺

N-(叔丁氧羰基)-1,4-丁二胺用途

NH2-C4-NH-Boc (compound 15) 是一种 PROTAC 连接桥,属于 Alkyl/ether 类。NH2-C4-NH-Boc 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体；一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

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N-(叔丁氧羰基)-1,4-丁二胺名称

[ CAS 号 ]:
68076-36-8

[ 中文名 ]:
N-叔丁氧羰基-1,4-丁二胺

[ 英文名 ]:
NH2-C4-NH-Boc

[中文别名 ]:

[英文别名 ]:

2-Methyl-2-propanyl (4-aminobutyl)carbamate
BOC-NH(CH2)4NH2 HCL
tert-butyl 4-aminobutylcarbamate
(4-amino-butyl)-carbamic acid tert-butyl ester
N-(1,1-dimethylethoxycarbonyl)-1,4-butanediamine
BOC-DIAMINOBUTANE HCL
N-Boc-1,4-butanediamine
N-Boc-1,4-butandiamine
N-T-BOC-BUTANDIAMINE HCL
BUTTPARK 121 6-09

N-(叔丁氧羰基)-1,4-丁二胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[参考文献]

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

N-(叔丁氧羰基)-1,4-丁二胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
292.9±23.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₂₀N₂O₂

[ 分子量 ]:
188.267

[ 闪点 ]:
130.9±22.6 °C

[ 精确质量 ]:
188.152481

[ PSA ]:
64.35000

[ LogP ]:
1.06

[ 外观性状 ]:
液体;Colorless to Almost colorless clear liquid

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.457

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

N-(叔丁氧羰基)-1,4-丁二胺MSDS

N-(叔丁氧羰基)-1,4-丁二胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
3

[ 危险类别 ]:
8.0

[ 海关编码 ]:
2924199090

N-(叔丁氧羰基)-1,4-丁二胺合成路线

N-(叔丁氧羰基)-1,4-丁二胺上下游产品

N-(叔丁氧羰基)-1,4-丁二胺上游产品

N-(叔丁氧羰基)-1,4-丁二胺下游产品

N-(叔丁氧羰基)-1,4-丁二胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-(叔丁氧羰基)-1,4-丁二胺文献

Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.

Biopolymers 104 , 206-12, (2015)

Recently, we described a process of trypsin-assisted peptide splicing of analogs of trypsin inhibitor SFTI-1, that seems to be very similar to proteasome-catalyzed peptide splicing. Here, we show, for...

Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.

J. Med. Chem. 32 , 409, (1989)

In an attempt to identify a soluble oncodazole analogue that could be easily formulated, a series of substituted oncodazoles was synthesized and evaluated for tubulin binding affinity, in vitro cytoto...

Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria.

J. Med. Chem. 45 , 2056, (2002)

Several iron chelators containing alpha,beta-unsaturated hydroxamic acid motifs appended to a citric acid platform were synthesized. Mycobacterium paratuberculosis was then challenged to grow in the p...

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