氨磺丁脲
氨磺丁脲用途
氨磺丁脲名称
[ CAS 号 ]:
339-43-5
[ 中文名 ]:
氨磺丁脲
[ 英文名 ]:
Carbutamide
[英文别名 ]:
- Glybutamide
- 1-butyl-3-sulfanilylurea
- Bukarban
- N-Butyl-N'-sulfanilyl-harnstoff
- Glucidoral
- Bucarban
- Carbutamid
- Butisulfina
- tolbutamide
- N-butyl-N'-sulfanilyl-urea
氨磺丁脲生物活性
[ 描述 ]:
[ 相关类别 ]:
[体内研究]
[参考文献]
氨磺丁脲物理化学性质
[ 密度 ]:
1.266g/cm3
[ 熔点 ]:
144-145ºC
[ 分子式 ]:
C11H17N3O3S
[ 分子量 ]:
271.33600
[ 精确质量 ]:
271.09900
[ PSA ]:
109.67000
[ LogP ]:
3.50060
[ 外观性状 ]:
固体
[ 折射率 ]:
1.564
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放
氨磺丁脲MSDS
氨磺丁脲毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS4200000
- CHEMICAL NAME :
- Urea, 1-butyl-3-sulfanilyl-
- CAS REGISTRY NUMBER :
- 339-43-5
- BEILSTEIN REFERENCE NO. :
- 2218915
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C11-H17-N3-O3-S
- MOLECULAR WEIGHT :
- 271.37
- WISWESSER LINE NOTATION :
- ZR DSWMVM4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,93,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 980 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,93,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1920 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 307 gm/kg/29W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - other changes Related to Chronic Data - death
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 6 gm/kg/24D-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Endocrine - other changes Related to Chronic Data - death
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 40950 mg/kg/78W-I
- TOXIC EFFECTS :
- Blood - hemorrhage Nutritional and Gross Metabolic - dehydration Related to Chronic Data - death
- REFERENCE :
- HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 119,185,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 36500 mg/kg/10W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death
- REFERENCE :
- DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 6,2,1957 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1056 mg/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,151,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 gm/kg
- SEX/DURATION :
- female 9-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - homeostasis
- REFERENCE :
- ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 19,167,1958
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3200 mg/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,151,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 12 gm/kg
- SEX/DURATION :
- female 1-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- REFERENCE :
- BANMAC Bulletin de l'Academie Nationale de Medicine (Paris). (Imprimeries Reunies de Chambray, 226, route d'Apremont, F-73490 La Ravoire, France) V.1- 1836- Volume(issue)/page/year: 143,238,1959
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
- REFERENCE :
- AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 42(12),35,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 42(12),35,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 42(12),35,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 4400 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981. Volume(issue)/page/year: 71,289,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 4400 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981. Volume(issue)/page/year: 71,289,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 8800 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981. Volume(issue)/page/year: 71,289,1969 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,408,1963
氨磺丁脲安全信息
[ 危害码 (欧洲) ]:
Xn
[ 海关编码 ]:
2935009090
氨磺丁脲合成路线
氨磺丁脲上下游产品
氨磺丁脲上游产品
氨磺丁脲下游产品
氨磺丁脲海关
[ 海关编码 ]: 2935009090
[ 中文概述 ]:
2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
推荐生产厂家/供应商:
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥1235.9/250mg
¥413.9/50mg
¥1770.9/1g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:Carbutamide
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥574.0/50mg
¥2293.0/250mg
联系人:夏言
产品详情:[Perfemiker]Carbutamide,98%
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相关化合物
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