异丙隆
异丙隆用途
异丙隆名称
[ CAS 号 ]:
34123-59-6
[ 中文名 ]:
异丙隆
[ 英文名 ]:
Isoproturon
[中文别名 ]:
[英文别名 ]:
- N,N-Dimethyl-N'-(4-(1-methylethyl)phenyl)urea
- N,N-Dimethyl-N'-[4-(1-methylethyl)phenyl]urea
- Protugan
- N,N-dimethyl-N’-[4-(1-methylethyl)phenyl]urea
- Tolkan
- 1,1-dimethyl-3-[4-(propan-2-yl)phenyl]urea
- I.P.U.
- Isoproturon
- Graminon
- Urea, N,N-dimethyl-N'-[4-(1-methylethyl)phenyl]-
异丙隆生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
异丙隆物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
353.2±25.0 °C at 760 mmHg
[ 熔点 ]:
155-156ºC
[ 分子式 ]:
C12H18N2O
[ 分子量 ]:
206.284
[ 闪点 ]:
167.4±23.2 °C
[ 精确质量 ]:
206.141907
[ PSA ]:
32.34000
[ LogP ]:
2.32
[ 外观性状 ]:
无色固体
[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C
[ 折射率 ]:
1.555
[ 储存条件 ]:
APPROX 4°C
异丙隆MSDS
异丙隆毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT0170000
- CHEMICAL NAME :
- Urea, 1,1-dimethyl-3-(p-isopropylphenyl)-
- CAS REGISTRY NUMBER :
- 34123-59-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C12-H18-N2-O
- MOLECULAR WEIGHT :
- 206.32
- WISWESSER LINE NOTATION :
- 1Y1&R DMVN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1826 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >670 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1043 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >9 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 3042 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48 gm/kg/10W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 gm/kg/3W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg/5D (Intermittent)
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 28,862,1990
异丙隆安全信息
[ 符号 ]:
GHS07, GHS08, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H332-H351-H410
[ 警示性声明 ]:
P273-P281-P501
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi:Irritant
[ 风险声明 (欧洲) ]:
R40;R50/53
[ 安全声明 (欧洲) ]:
S36/37-S60-S61-S26
[ 危险品运输编码 ]:
UN 3077
[ RTECS号 ]:
YT0170000
[ 包装等级 ]:
III
[ 海关编码 ]:
2924299039
异丙隆合成路线
异丙隆上下游产品
异丙隆上游产品
异丙隆下游产品
异丙隆制备
1、 由对异丙基苯异氰酸酯与二甲胺反应而得。将33%的二甲胺水溶液加入反应瓶,加水,冷却至0-5℃时,加速搅拌,滴加对异丙基苯异氰酸酯。在0-5℃下搅拌反应2h,抽滤,将滤饼在丙酮中重结晶即得成品。原料消耗定额:对异丙基苯胺(95%)980kg/t、二甲胺(40%)950kg/t、光气(80%)840kg/t、氯气570kg/t。
2、 异氰酸酯法
异氰酸异丙苯酯的制备 以甲苯为溶剂,4-异丙基苯胺与光气作用生成异氰酸异丙苯酯。
异丙隆的合成 异氰酸异丙苯酯与二甲胺加及生成异丙隆。投料经为异氰酸酯:二甲胺=1:1 (mol比);滴加温度15℃,时间20min;反应温度20~30℃,时间2h。以水为溶剂,收率95%。
氨基甲酰氯法
先制备N,N-二甲基氨基甲酰氯的制备; 再与4-异丙基苯胺作用合成异丙隆。
非光气法
对异遭受基三氯乙酰苯胺的制备 将13.5g (0.1mol)对异丙基苯胺和16.5g (0.1mol)三氯乙酸混合后,搅拌下滴加14.0g (0.1mol)三氯化磷,温度控制在100~110℃,滴毕恒温反应30min,然后加入100mL冰水,抽滤收集固体并用水洗至中性,用乙醇/水重结晶,得白色结晶,收率91%, m.p.123~125℃。
异丙隆的合成 将14.0g (0.05mol)对异丙基三氯乙酰苯胺、5.0g(0.125mol)氢氧化钠、4.5g (0.10mol)二甲胺和80mL二甲苯亚砜加入反应器中,于60~80℃反应30min,反应毕倾入水中,抽滤收集固体,用乙醇/水重结晶,得白色固体,收率95%,m.p.152~154℃。
据Atanassova, I.A.报道,此反应过程可能是对异丙基三氯乙酰苯胺在碱的作用下,首先生成中间体对异丙基异氰酸苯酯,然后立即与二甲胺作用生成异丙醇。
采用非光气法合成异丙隆,还可用尿素代替光气,在水溶液中与对异丙基苯胺反应,生成中间体对异丙基苯脲,然后再与二甲胺水溶液反应,合成异丙隆,总收率达76%。
异丙隆海关
[ 海关编码 ]: 2924299039
[ 中文概述 ]:
2924299039 乙酰甲草胺、异丙隆、异草完隆等〔包括异丙草胺、异丁草胺〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 包装
[ 监管条件 ]: S.进出口农药登记证明
[ Summary ]:
2924299039. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:S(import or export registration certificate for pesticides). MFN tariff:6.5%. General tariff:30.0%
异丙隆文献
J. Chromatogr. A. 1418 , 140-9, (2015)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of...
Simultaneous extraction and determination of various pesticides in environmental waters.J. Sep. Sci. 37(24) , 3699-705, (2014)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect...
Multiresidue method for the determination of 13 pesticides in three environmental matrices: water, sediments and fish muscle.Talanta 85(3) , 1500-7, (2011)
Pesticides residues in aquatic ecosystems are an environmental concern which requires efficient analytical methods. In this study, we proposed a generic method for the quantification of 13 pesticides ...
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价格:
¥218.0/1ml
联系人:刘佳
产品详情:异丙隆
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区域:上海市浦东新区
价格:
¥298.9/100mg
¥1750.9/1g
¥需询单/1g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:异丙隆
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥188.0/1ml
联系人:夏言
产品详情:[Perfemiker]异丙隆,100μg/mL,U(%)=2,介质:甲醇
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