二甲氨基甲酰氯
二甲氨基甲酰氯用途
二甲氨基甲酰氯名称
[ CAS 号 ]:
79-44-7
[ 中文名 ]:
二甲氨基甲酰氯
[ 英文名 ]:
dmcl
[中文别名 ]:
[英文别名 ]:
- N,N-dimethyl-carbamic acid chloride
- Carbamic chloride, dimethyl-
- rcrawastenumberu097
- dimethylaminocarbamoyl chloride
- dmcc
- MFCD00000635
- DMCF
- N,N-dimethylaminocarbonyl chloride
- N,N-dimethyl carbamyl chloride
- DMCL
二甲氨基甲酰氯物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
166.8±0.0 °C at 760 mmHg
[ 熔点 ]:
−33 °C(lit.)
[ 分子式 ]:
C3H6ClNO
[ 分子量 ]:
107.539
[ 闪点 ]:
68.3±0.0 °C
[ 精确质量 ]:
107.013794
[ PSA ]:
20.31000
[ LogP ]:
0.24
[ 外观性状 ]:
透明液体
[ 蒸汽压 ]:
1.8±0.3 mmHg at 25°C
[ 折射率 ]:
1.436
[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)
[ 水溶解性 ]:
Decomposes
二甲氨基甲酰氯MSDS
二甲氨基甲酰氯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FD4200000
- CHEMICAL NAME :
- Carbamoyl chloride, dimethyl-
- CAS REGISTRY NUMBER :
- 79-44-7
- BEILSTEIN REFERENCE NO. :
- 0878197
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 63
- MOLECULAR FORMULA :
- C3-H6-Cl-N-O
- MOLECULAR WEIGHT :
- 107.55
- WISWESSER LINE NOTATION :
- GVN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 180 ppm/6H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 mg/m3/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 ppm/6H/6W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17280 mg/kg/72W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2560 mg/kg/64W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 894 mg/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1 ppm/6H/89W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 gm/kg/55W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 gm/kg/40W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 ppm/6H/6W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 ppm
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5200 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 gm/kg/55W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1 ppm/6H/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,103,1983 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen, NO TWA DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,77,1976 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,77,1976 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,199,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Carcinogen JAN 1993 OEL-BELGIUM;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLCARBAMOYLCHLORIDE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
二甲氨基甲酰氯安全信息
[ 符号 ]:
GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H315-H319-H331-H335-H350
[ 警示性声明 ]:
P201-P261-P280-P304 + P340 + P312-P308 + P313-P403 + P233
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R45;R22;R23;R36/37/38
[ 安全声明 (欧洲) ]:
S53-S45
[ 危险品运输编码 ]:
UN 2262 8/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
FD4200000
[ 包装等级 ]:
II
[ 危险类别 ]:
8
二甲氨基甲酰氯合成路线
二甲氨基甲酰氯上下游产品
二甲氨基甲酰氯上游产品
二甲氨基甲酰氯下游产品
二甲氨基甲酰氯制备
由二甲胺与光气反应制得，反应式如下：
将甲苯加入反应锅内，在冷却的条件下通入光气吸收至计算量。在另一锅中由二甲胺水溶液发生气体二甲胺，经干燥后通入光气甲苯溶液中反应。反应结束后过滤除去盐酸盐，减压蒸馏，收集75（3.33kPa）馏分即为二甲氨基甲酰氯，收率55%。
另外，二甲氨基甲酰氯还可以由N,N-二甲基甲酰胺与三氯化磷反应后再与氯化亚砜制得。或者以Pd，PdCl2或RhCl3为催化剂，由二甲基氯化铵与一氧化碳直接反应得到。
二甲氨基甲酰氯文献
Anal. Biochem. 170(2) , 451-5, (1988)
An improved method for assaying carbamylated acetylcholinesterase is described which has substantial benefits over current methods. Acetylcholinesterase was carbamylated with neostigmine and diluted e...
Dimethylcarbamoyl chloride.Rep. Carcinog. 12 , 171-2, (2011)
Dimethylcarbamoyl chloride.
Rep. Carcinog. 11 , III107, (2004)
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：二甲氨基甲酰氯
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥118.0/100g
￥348.0/500g
联系人：刘佳
产品详情：二甲氨基甲酰氯
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥371.0/500g
￥46.0/25g
￥92.0/100g
￥需询单/1g
联系人：阿拉丁
产品详情：二甲氨基甲酰氯
查看所有供应商请点击：
相关化合物
【二甲氨基甲酰氯】化源网提供二甲氨基甲酰氯CAS号79-44-7，二甲氨基甲酰氯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询二甲氨基甲酰氯上化源网，专业又轻松。>>电脑版：二甲氨基甲酰氯
标题：二甲氨基甲酰氯_MSDS_用途_密度_CAS号【79-44-7】_化源网 地址：https://m.chemsrc.com/mip/cas/79-44-7_895375.html