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腺苷.高碘酸氧化

腺苷.高碘酸氧化用途

Adenosine Dialdehyde 是嘌呤核苷的类似物,是 S-腺苷同型半胱氨酸水解酶 (SAH) 的不可逆抑制剂 (IC50=40 nM)。Adenosine Dialdehyde 具有较强的抗肿瘤活性,可用于肿瘤研究。

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腺苷.高碘酸氧化名称

[ CAS 号 ]:
34240-05-6

[ 中文名 ]:
腺苷.高碘酸氧化

[ 英文名 ]:
Adenosine dialdehyde

[英文别名 ]:

ADENOSINE, PERIODATE OXIDIZED
α-adenosine 2',3'-dialdehyde
ADENOSINE, PERIODATE OXIDISED
Adenosine Dialdehyde

腺苷.高碘酸氧化生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[体外研究]

腺苷双醛在组织培养中抑制MNB细胞复制,浓度为1.5μM,抑制率为50%。

[体内研究]

腺苷二醛(皮下注射；1.5-2.5 mg/kg；7天内注射(小泵输注))可显著延长荷瘤小鼠的平均寿命,从稀释液处理的对照组的20.9天增加到AD治疗组的35.3天[2]。腺苷二醛(皮下注射；1.5-2.5 mg/kg；两个7天的周期,中间穿插7天的无药物间隔(小泵输注))使小鼠的平均寿命增加80%(对照组,21.3天；AD治疗38.4天)[2]。腺苷二醛(皮下注射；2-3mg/kg；7天内输注(小泵输注))对小鼠无造血毒性,可显著抑制小鼠神经母细胞瘤肿瘤生长,全身毒性小[2]。动物模型：成年雄性A/J小鼠,体重20-25g,含MNB细胞[2]剂量：1.5-2.5mg/kg给药：皮下注射；1.5-2.5mg/kg；两次7天间隔,间隔7天(小泵输注)结果：显著抑制小鼠神经母细胞瘤肿瘤生长。延长荷瘤小鼠的寿命。稳态输注时未抑制造血[2]。

[参考文献]

[1]. G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem

[2]. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6.

腺苷.高碘酸氧化物理化学性质

[ 分子式 ]:
C₁₀H₁₁N₅O₄

[ 分子量 ]:
265.22500

[ 精确质量 ]:
265.08100

[ PSA ]:
133.22000

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

腺苷.高碘酸氧化MSDS

详细MSDS(安全技术说明书)

腺苷.高碘酸氧化安全信息

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

腺苷.高碘酸氧化海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

腺苷.高碘酸氧化文献

Elasticity assessment of electrospun nanofibrous vascular grafts: a comparison with femoral ovine arteries.

Mater. Sci. Eng. C. Mater. Biol. Appl. 45 , 446-54, (2014)

Development of successful small-diameter vascular grafts constitutes a real challenge to biomaterial engineering. In most cases these grafts fail in-vivo due to the presence of a mechanical mismatch b...

Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate.

Blood Cells Mol. Dis. 50(1) , 1-7, (2013)

The main objective of the present study was to investigate if vanadate is extruded from the cells in a glutathione dependent manner resulting in the appearance of extracellular glutathione and complex...

Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde.

Biochem. Pharmacol. 85(8) , 1042-56, (2013)

Transmethylation is an important reaction that transfers a methyl group in S-adenosylmethionine (SAM) to substrates such as DNA, RNA, and proteins. It is known that transmethylation plays critical rol...

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