阿托伐他汀钙三水合物

阿托伐他汀钙三水合物用途

Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia.

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阿托伐他汀钙三水合物名称

[ CAS 号 ]:
344423-98-9

[ 中文名 ]:
阿托伐他汀钙三水合物

[ 英文名 ]:
atorvastatin calcium trihydrate

[中文别名 ]:

阿托伐他汀钙水合物

[英文别名 ]:

atorvastatin calcium trihydrate
Torvast
Atorvastatin Calcium Salt Trihydrate
Atorvastatin hemicalcium salt sesquihydrate
Lipitor
Sortis
Totalip

阿托伐他汀钙三水合物物理化学性质

[ 分子式 ]:
C₆₆H₇₄CaF₂N₄O₁₃

[ 分子量 ]:
1209.388

[ 精确质量 ]:
1208.484619

[ PSA ]:
256.93000

[ LogP ]:
9.91090

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
Very slightly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

阿托伐他汀钙三水合物安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H319-H360D

[ 警示性声明 ]:
P201-P280-P305 + P351 + P338-P308 + P313-P337 + P313

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
61-36

[ 安全声明 (欧洲) ]:
53-26-45

[ 危险品运输编码 ]:
NONH for all modes of transport

阿托伐他汀钙三水合物文献

Statins demonstrate a broad anti-cytomegalovirus activity in vitro in ganciclovir-susceptible and resistant strains.

J. Med. Virol. 87(1) , 141-53, (2014)

Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against ...

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015)

Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statin...

Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.

Biol. Chem. 396(1) , 71-80, (2014)

Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/...

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