阿托伐他汀钙三水合物
阿托伐他汀钙三水合物结构式
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常用名 | 阿托伐他汀钙三水合物 | 英文名 | atorvastatin calcium trihydrate |
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| CAS号 | 344423-98-9 | 分子量 | 1209.388 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C66H74CaF2N4O13 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Statins demonstrate a broad anti-cytomegalovirus activity in vitro in ganciclovir-susceptible and resistant strains.
J. Med. Virol. 87(1) , 141-53, (2014) Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against human cytomegalovirus (HCMV), a risk factor in the pathogen... |
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Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.
Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015) Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statins are useful probes for OATP-mediated DDI, endogenous probe... |
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Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.
Biol. Chem. 396(1) , 71-80, (2014) Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/macrophages. Macrophages were derived from M-CSF- or GM-CSF... |
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Macitentan does not interfere with hepatic bile salt transport.
J. Pharmacol. Exp. Ther. 350(1) , 130-43, (2014) Treatment of pulmonary arterial hypertension with the endothelin receptor antagonist bosentan has been associated with transient increases in liver transaminases. Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic a... |
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Synergistic effect of hydrotrope and surfactant on solubility and dissolution of atorvastatin calcium: screening factorial design followed by ratio optimization.
Indian J. Pharm. Sci. 76(6) , 483-94, (2015) The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients and manufacturing methods on solubil... |
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PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Cancer Cell Int. 15 , 27, (2015) PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumors, and functions in tumorigenesis and metastasis. However, ... |
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Protective effects of some statins on epileptogenesis and depressive-like behavior in WAG/Rij rats, a genetic animal model of absence epilepsy.
Epilepsia 55(8) , 1284-91, (2014) Statins (3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitors) exert cholesterol-independent pleiotropic effects that include antithrombotic, antiinflammatory, and antioxidative properties. Moreover, both in vitro and in vivo studies have show... |
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Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process.
Eur. J. Pharm. Biopharm. 69(2) , 454-65, (2008) In this work, amorphous atorvastatin calcium nanoparticles were successfully prepared using the supercritical antisolvent (SAS) process. The effect of process variables on particle size and distribution of atorvastatin calcium during particle formation was in... |
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Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight.
J. Physiol. 593(3) , 573-84, (2015) Weightlessness in space induces initially an increase in stroke volume and cardiac output, accompanied by unchanged or slightly reduced blood pressure.It is unclear whether these changes persist throughout months of flight.Here, we show that cardiac output an... |
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Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits.
J. Atheroscler. Thromb. 21(7) , 648-58, (2014) Probucol is a lipid-lowering drug that is often prescribed for the treatment of familial hypercholesterolemia. However, it is not known whether probucol can change the lesion quality of atherosclerosis.We examined this possibility using WHHL rabbits, a model ... |