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5-甲氧基吲哚-3-乙酸

5-甲氧基吲哚-3-乙酸用途

5-Methoxyindole-3-acetic acid,从松果体组织中分离出来,是 Melatonin 的一种代谢产物。

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5-甲氧基吲哚-3-乙酸名称

[ CAS 号 ]:
3471-31-6

[ 中文名 ]:
5-甲氧基吲哚-3-乙酸

[ 英文名 ]:
5-Methoxyindole-3-acetic acid

[中文别名 ]:

5-甲氧基-3-吲哚乙酸

[英文别名 ]:

5-Methoxy-3-indoleacetic acid
5-methoxy-1H-indole-3-acetic acid
5-Methoxyindole-3-aceticacid
2-(5-Methoxy-3-indolyl)acetic acid
5-Methoxyindoleacetate
5-Methoxyindoleacetic acid
MFCD00005638
EINECS 222-438-3
1H-Indole-3-acetic acid, 5-methoxy-, ion(1-)
5-Methoxyindol-3-ylacetate

5-甲氧基吲哚-3-乙酸生物活性

[ 描述 ]:

5-Methoxyindole-3-acetic acid,从松果体组织中分离出来,是 Melatonin 的一种代谢产物。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. KVEDER S, et al. The metabolism of melatonin (N-acetyl-5-methoxytryptamine) and 5-methoxytryptamine. J Biol Chem. 1961 Dec;236:3214-20.

5-甲氧基吲哚-3-乙酸物理化学性质

[ 沸点 ]:
445.9ºC at 760 mmHg

[ 熔点 ]:
145-148 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₁NO₃

[ 分子量 ]:
205.21000

[ 闪点 ]:
223.5ºC

[ 精确质量 ]:
205.07400

[ PSA ]:
62.32000

[ LogP ]:
1.80360

[ 外观性状 ]:
灰白色至淡棕色结晶粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
insoluble

5-甲氧基吲哚-3-乙酸MSDS

详细MSDS(安全技术说明书)

5-甲氧基吲哚-3-乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL3660500

CHEMICAL NAME :: Indole-3-acetic acid, 5-methoxy-

CAS REGISTRY NUMBER :: 3471-31-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H11-N-O3

MOLECULAR WEIGHT :: 205.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 98 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors

REFERENCE :: BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 101,605,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg female 10-21 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :: BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 101,605,1986

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5-甲氧基吲哚-3-乙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL3660500

[ 海关编码 ]:
2933990090

5-甲氧基吲哚-3-乙酸上下游产品

5-甲氧基吲哚-3-乙酸上游产品

5-甲氧基吲哚-3-乙酸下游产品

5-甲氧基吲哚-3-乙酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-甲氧基吲哚-3-乙酸文献

Indoleamines and 5-methoxyindoles in trout pineal organ in vivo: daily changes and influence of photoperiod.

Gen. Comp. Endocrinol. 144(1) , 67-77, (2005)

This study describes the diel rhythms in several indoleamines, melatonin, and related 5-methoxyindoles in the pineal organ of rainbow trout in vivo. In addition, the effect of different photoperiod co...

Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study.

Neuro Endocrinol. Lett. 24(3-4) , 259-62, (2003)

It is known since many years that the pineal gland plays an anticancer role, and melatonin (MLT), the most investigated pineal hormone, has been proven to exert antitumor activity. However, MLT would ...

Secretion of the methoxyindoles melatonin, 5-methoxytryptophol, 5-methoxyindoleacetic acid, and 5-methoxytryptamine from trout pineal organs in superfusion culture: effects of light intensity.

Gen. Comp. Endocrinol. 101(2) , 165-72, (1996)

The teleost pineal organ is a photoreceptive endocrine organ that synthesizes the hormone melatonin through specialized intrapineal photoreceptor cells in a light-dependent manner. The present study i...

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