Tomaymycin

Tomaymycin用途

托马霉素是一种抗肿瘤抗生素。托马霉素对革兰氏阳性细菌具有抗菌活性[1][2]。

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Tomaymycin名称

[ CAS 号 ]:
35050-55-6

[ 英文名 ]:
Tomaymycin

Tomaymycin生物活性

[ 描述 ]:

托马霉素是一种抗肿瘤抗生素。托马霉素对革兰氏阳性细菌具有抗菌活性[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

[ 靶点 ]

Antibiotic[1][2]

[体内研究]

托马斯霉素是一种抗噬菌体抗生素,由无色链霉菌变种托马斯霉素在富含酵母抽提物和磷酸盐的乳糖肉汤培养基中培养产生。对大肠杆菌T1、T3噬菌体和枯草芽孢杆菌M-2、SP-10噬菌体具有较强的抗噬菌体活性。番茄霉素对小鼠的LD50(i.p.)估计为3.0 mg/kg。

[参考文献]

[1]. F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403.

[2]. K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44.

Tomaymycin物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
541.2ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₂₀N₂O₄

[ 分子量 ]:
304.34100

[ 闪点 ]:
281.1ºC

[ 精确质量 ]:
304.14200

[ PSA ]:
71.03000

[ LogP ]:
2.03550

[ 折射率 ]:
1.622

Tomaymycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8533000

CHEMICAL NAME :: 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy- 7,11-dimethoxy-, (11R-(2E,11-alpha,11a-beta))-

CAS REGISTRY NUMBER :: 35050-55-6

LAST UPDATED :: 199509

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H20-N2-O4

MOLECULAR WEIGHT :: 304.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3540 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 100 ng/plate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983