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炔诺肟酯

炔诺肟酯用途

Norgestimate 是一种合成的孕激素类似物,一种具有口服活性,高度选择性的孕激素活性和最小雄激素作用的孕激素 (progestin)。Norgestimate 可用于口服避孕药。

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炔诺肟酯名称

[ CAS 号 ]:
35189-28-7

[ 中文名 ]:
诺孕酯

[ 英文名 ]:
Norgestimate

[中文别名 ]:

[英文别名 ]:

dexnorgestrelacetime
Norgestimat
Norgestimate
NORGESTIMATE,USP STANDARD
levonorgestrel acetate 3-oxime

炔诺肟酯生物活性

[ 描述 ]:

Norgestimate 是一种合成的孕激素类似物,一种具有口服活性,高度选择性的孕激素活性和最小雄激素作用的孕激素 (progestin)。Norgestimate 可用于口服避孕药。

[ 相关类别 ]:

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

[体外研究]

炔诺孕酮至少转化为两种活性代谢物：左炔诺孕酮3-肟(去乙酰化炔诺孕酮；炔诺孕酮)和左炔诺孕酮[1]。

[参考文献]

[1]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90.

[2]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

炔诺肟酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
497.9±45.0 °C at 760 mmHg

[ 熔点 ]:
216ºC

[ 分子式 ]:
C₂₃H₃₁NO₃

[ 分子量 ]:
369.497

[ 闪点 ]:
254.9±28.7 °C

[ 精确质量 ]:
369.230408

[ PSA ]:
58.89000

[ LogP ]:
5.00

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.611

炔诺肟酯MSDS

炔诺肟酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JF7976000

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)-

CAS REGISTRY NUMBER :: 35189-28-7

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H31-N-O3

MOLECULAR WEIGHT :: 369.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 mg/kg

SEX/DURATION :: female 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977

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炔诺肟酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H361fd

[ 警示性声明 ]:
P281-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63-22-36/38-62

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
JF7976000

炔诺肟酯合成路线

炔诺肟酯上下游产品

炔诺肟酯上游产品

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炔诺肟酯文献

Types of combined oral contraceptives used by US women.

Contraception 86(6) , 659-65, (2012)

We sought to estimate the prevalence of types of combined oral contraceptives (COCs) used among US women.We analyzed interview-collected data from 12,279 women aged 15-44 years participating in the Na...

Mechanosensitive ATP release from hemichannels and Ca²⁺ influx through TRPC6 accelerate wound closure in keratinocytes.

J. Cell Sci. 127(Pt 19) , 4159-71, (2014)

The study aimed to investigate the effect of inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity on tau phosphorylation in HEK293/tau441 cells and its mechanism. HEK293/tau441 cells were tre...

Progestins in preventive hormone therapy. Including pharmacology of the new progestins, desogestrel, norgestimate, and gestodene: are there advantages?

Obstet. Gynecol. Clin. North Am. 21(2) , 299-319, (1994)

Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofa...

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