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[PYR]HWSYGLRPG-OH

[PYR]HWSYGLRPG-OH用途

促黄体生成素释放激素LHRH是下丘脑的一种神经肽。LHRH调节生殖。LHRH可用于癌症的研究[1]。

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[PYR]HWSYGLRPG-OH名称

[ CAS 号 ]:
35263-73-1

[ 中文名 ]:
[PYR]HWSYGLRPG-OH

[ 英文名 ]:
LHRH (free acid) trifluoroacetate salt

[英文别名 ]:

PYR-HWSYGLRPG
GONADOTROPIN-RELEASING HORMONE
PYR-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY
LUTEINIZING HORMONE-RELEASING HORMONE
mammalian GnRH I
luteinizing hormone releasing hormone free acid
pEHWSYGLRPG
<Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH >
GLP-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH

[PYR]HWSYGLRPG-OH生物活性

[ 描述 ]:

促黄体生成素释放激素LHRH是下丘脑的一种神经肽。LHRH调节生殖。LHRH可用于癌症的研究[1]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体

研究领域 >> 内分泌

[参考文献]

[1]. Schally AV, et, al. Discovery of LHRH and development of LHRH analogs for prostate cancer treatment. Prostate. 2017 Jun;77(9):1036-1054.

[2]. Pearce TR, et, al. Peptide targeted lipid nanoparticles for anticancer drug delivery. Adv Mater. 2012 Jul 24;24(28):3803-22, 3710.

[PYR]HWSYGLRPG-OH物理化学性质

[ 密度 ]:
1.54 g/cm3

[ 分子式 ]:
C₅₅H₇₄N₁₆O₁₄

[ 分子量 ]:
1183.27

[ 精确质量 ]:
1182.56000

[ PSA ]:
466.34000

[ LogP ]:
1.00640

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.709

[PYR]HWSYGLRPG-OH安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R60

[ 安全声明 (欧洲) ]:
53-22-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[PYR]HWSYGLRPG-OH合成路线

详细合成路线

[PYR]HWSYGLRPG-OH文献

Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.

J. Neuroendocrinol. 26(12) , 888-97, (2014)

RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroen...

Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.

Mol. Cell. Endocrinol. 402 , 95-106, (2015)

Transmembrane helix seven residues of G protein-coupled receptors (GPCRs) couple agonist binding to a conserved receptor activation mechanism. Amino-terminal residues of the GnRH peptide determine ago...

Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study.

Reprod. Biomed. Online 30(4) , 340-8, (2015)

The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfe...

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