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5-甲氧基尿苷

5-甲氧基尿苷用途

5-甲氧基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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5-甲氧基尿苷名称

[ CAS 号 ]:
35542-01-9

[ 中文名 ]:
5-甲氧基尿苷

[ 英文名 ]:
5-methoxyuridine

[英文别名 ]:

5-OMe-uridine
5-METHOXYURIDINE

5-甲氧基尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

5-甲氧基尿苷物理化学性质

[ 密度 ]:
1.65±0.1 g/cm3(Predicted)

[ 分子式 ]:
C₁₀H₁₄N₂O₇

[ 分子量 ]:
274.23

[ 精确质量 ]:
274.08000

[ PSA ]:
134.01000

[ 储存条件 ]:
2-8°C

5-甲氧基尿苷安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

5-甲氧基尿苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-甲氧基尿苷文献

Codon recognition by tRNA molecules with a modified or unmodified uridine at the first position of the anticodon.

Nucleic Acids Symp. Ser. 34 , 203-204, (1995)

Effects of a single nucleoside modification at the first position of the anticodon of a transfer RNA molecule on its codon reading properties were investigated by use of a cell-free protein synthesis....

5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis.

Nucleic Acids Res. 3 , 2851-2860, (1976)

The sequences of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis W 168 were N-G-C, N-G-U, and N-A-C, respectively. A new minor constituent, N, occupied the first position of the ...

Bacillus subtilis tRNA(Pro) with the anticodon mo5UGG can recognize the codon CCC.

Biochim. Biophys. Acta 1728 , 143-149, (2005)

In Bacillus subtilis, four codons, CCU, CCC, CCA, and CCG, are used for proline. There exists, however, only one proline-specific tRNA having the anticodon mo(5)UGG. Here, we found that this tRNA(Pro)...

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