< 生产厂家 价格 >

美坦新

美坦新用途

Maytansine是一种高效微管靶向化合物,在亚纳摩尔浓度下诱导有丝分裂停止并杀死肿瘤细胞[1]。
点击显示

美坦新名称

[ CAS 号 ]:
35846-53-8

[ 中文名 ]:
美坦新

[ 英文名 ]:
maytansine

[英文别名 ]:

美坦新生物活性

[ 描述 ]:

Maytansine是一种高效微管靶向化合物,在亚纳摩尔浓度下诱导有丝分裂停止并杀死肿瘤细胞[1]。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 其他 >> 其他

[体外研究]

在6x10-8M处,美坦辛不可逆地抑制海胆和蛤蜊卵中的细胞分裂。如果在早期添加,美坦辛会导致有丝分裂器的消失或阻止有丝分裂器的形成。梅坦辛确实抑制微管蛋白的体外聚合。Maytansine抑制微管蛋白的体外聚合[2]。

[参考文献]

[1]. Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010;9(10):2689-2699.

[2]. Remillard S, et al. Antimitotic activity of the potent tumor inhibitor maytansine. Science. 1975;189(4207):1002-1005.

美坦新物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
895.1ºC at 760mmHg

[ 分子式 ]:
C34H46ClN3O10

[ 分子量 ]:
692.19600

[ 闪点 ]:
495.1ºC

[ 精确质量 ]:
691.28700

[ PSA ]:
156.47000

[ LogP ]:
3.92820

[ 折射率 ]:
1.59

[ 储存条件 ]:
-20°C，密闭，干燥

美坦新毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OQ2290000
CHEMICAL NAME :
Maytansine
CAS REGISTRY NUMBER :
35846-53-8
LAST UPDATED :
199801
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C34-H46-Cl-N3-O10
MOLECULAR WEIGHT :
692.28
WISWESSER LINE NOTATION :
T D3 K6-19-6 A K- EO IVN WNVO QU SUTJ C1 GOVY1&N1&V1 J1 LG MO1 Q1 UO1 VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
190 ug/kg/5D
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
480 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1530 ug/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia Skin and Appendages - hair
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1305 ug/kg/7W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 ug/kg/5D-I
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Blood - pigmented or nucleated red blood cells Blood - leukopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 ug/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 ug/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 ug/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
250 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 ug/kg
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 60,649,1978
点击显示

美坦新合成路线

详细合成路线

美坦新上下游产品

美坦新上游产品

美坦新下游产品

推荐生产厂家/供应商：

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Maytansine

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥3029.0/10mg ￥8494.0/50mg

联系人：夏言

产品详情：[Perfemiker]Maytansine,98%

查看所有供应商请点击：

美坦新供应商

相关化合物

【美坦新】化源网提供美坦新CAS号35846-53-8，美坦新MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询美坦新上化源网，专业又轻松。>>电脑版：美坦新

标题：美坦新_用途_密度_沸点_美坦新CAS号【35846-53-8】_化源网 地址：https://m.chemsrc.com/mip/cas/35846-53-8_443425.html