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A1受体拮抗剂,CPT

A1受体拮抗剂,CPT用途

8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) 是一种选择性的腺苷 A1 受体拮抗剂,对 A1 受体和 A2 受体的 Ki 值分别为 10.9 nM 和 1440 nM。

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A1受体拮抗剂,CPT名称

[ CAS 号 ]:
35873-49-5

[ 中文名 ]:
A1受体拮抗剂,CPT

[ 英文名 ]:
8-Cyclopentyl-1,3-dimethylxanthine

[中文别名 ]:

8-环戊-1,3-二甲基黄嘌呤

[英文别名 ]:

8-Cyclopentyltheophylline CPT
8-Cyclopentyl-1,3-dimethylxanthine
8-Cyclopentyl theophylline
Theophylline,8-cyclopentyl
cyclopentyl teophylline
1,3-dimethyl-8-cyclopentylxanthine
Xanthine,8-cyclopentyl-1,3-dimethyl

A1受体拮抗剂,CPT生物活性

[ 描述 ]:

8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) 是一种选择性的腺苷 A1 受体拮抗剂,对 A1 受体和 A2 受体的 Ki 值分别为 10.9 nM 和 1440 nM。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

Ki: 10.9 nM (A1 receptor), 1440 nM (A2 receptor)[1]

[参考文献]

[1]. K A Jacobson, et al. Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. J Med Chem. 1989 Aug;32(8):1873-9.

A1受体拮抗剂,CPT物理化学性质

[ 密度 ]:
1.332g/cm3

[ 沸点 ]:
513.1ºC at 760mmHg

[ 熔点 ]:
250-252ºC

[ 分子式 ]:
C₁₂H₁₆N₄O₂

[ 分子量 ]:
248.28100

[ 闪点 ]:
264.1ºC

[ 精确质量 ]:
248.12700

[ PSA ]:
72.68000

[ LogP ]:
0.61790

[ 折射率 ]:
1.607

[ 储存条件 ]:
2-8°C，密封，干燥

A1受体拮抗剂,CPTMSDS

详细MSDS(安全技术说明书)

A1受体拮抗剂,CPT毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5093600

CHEMICAL NAME :: Theophylline, 8-cyclopentyl-

CAS REGISTRY NUMBER :: 35873-49-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H16-N4-O2

MOLECULAR WEIGHT :: 248.32

WISWESSER LINE NOTATION :: T56 BM DN FNVNVJ F1 H1 C- AL5TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1202,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06862

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A1受体拮抗剂,CPT安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XH5093600

[ 海关编码 ]:
2933990090

A1受体拮抗剂,CPT上下游产品

A1受体拮抗剂,CPT上游产品

A1受体拮抗剂,CPT下游产品

A1受体拮抗剂,CPT海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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