盐酸妥卡尼
盐酸妥卡尼名称
[ CAS 号 ]:
35891-93-1
[ 中文名 ]:
盐酸妥卡尼
[ 英文名 ]:
Tocainide HCl
[中文别名 ]:
[英文别名 ]:
- Xylotocan
- Unii-2K7I38ckn5
- tonocardhydrochloride
- TOCAINIDE HCL
盐酸妥卡尼物理化学性质
[ 沸点 ]:
330.1ºC at 760 mmHg
[ 熔点 ]:
244-245 °C
[ 分子式 ]:
C11H17ClN2O
[ 分子量 ]:
228.71800
[ 闪点 ]:
153.5ºC
[ 精确质量 ]:
228.10300
[ PSA ]:
55.12000
[ LogP ]:
3.16440
[ 外观性状 ]:
固体
[ 储存条件 ]:
-20°C
盐酸妥卡尼毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TX1404500
- CHEMICAL NAME :
- Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 35891-93-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H16-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 228.75
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 48 mg/kg/2D-I
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,79,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 257 mg/kg/15D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Taste) - change in function Behavioral - tremor Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,142,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 360 mg/kg/6W-I
- TOXIC EFFECTS :
- Blood - normocytic anemia Blood - agranulocytosis
- REFERENCE :
- AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 147,598,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 529 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,192,1973
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