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盐酸妥拉唑林

盐酸妥拉唑林用途

Tolazoline(NSC35110; Imidaline)盐酸盐是_alpha_-肾上腺素受体抑制剂。

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盐酸妥拉唑林名称

[ CAS 号 ]:
59-97-2

[ 中文名 ]:
盐酸妥拉唑林

[ 英文名 ]:
Tolazoline hydrochloride

[中文别名 ]:

[英文别名 ]:

2-benzyl-4,5-dihydro-1H-imidazole chlorhydrate
2-benzyl-4,5-dihydro-1H-imidazole,hydrochloride
Vasodilatan
EINECS 200-447-3
TCMDC-125842
2-Benzyl-4,5-dihydro-1H-imidazolhydrochlorid
MFCD00012693
2-Benzyl-4,5-dihydro-1H-imidazolhydrochlorid(1:1)
priscol

盐酸妥拉唑林生物活性

[ 描述 ]:

Tolazoline(NSC35110; Imidaline)盐酸盐是_alpha_-肾上腺素受体抑制剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 其他

[参考文献]

[1]. Tolazoline, From Wikipedia

[相关活性小分子]

盐酸妥拉唑林物理化学性质

[ 密度 ]:
1.09g/cm3

[ 沸点 ]:
338.2ºC at 760mmHg

[ 熔点 ]:
172-176 °C

[ 分子式 ]:
C₁₀H₁₃ClN₂

[ 分子量 ]:
196.677

[ 闪点 ]:
158.3ºC

[ 精确质量 ]:
196.076721

[ PSA ]:
24.39000

[ LogP ]:
1.79720

[ 外观性状 ]:
淡黄色结晶固体

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Hygroscopic

盐酸妥拉唑林MSDS

详细MSDS(安全技术说明书)

盐酸妥拉唑林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2350000

CHEMICAL NAME :: 2-Imidazoline, 2-benzyl-, monohydrochloride

CAS REGISTRY NUMBER :: 59-97-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H12-N2.Cl-H

MOLECULAR WEIGHT :: 196.70

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 48 mg/kg/47H-C

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from duodenum Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: AUPJB7 Australian Paediatric Journal. (Royal Childrens Hospital, Parkville, Vic., Australia) V.1- 1965- Volume(issue)/page/year: 22,221,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 150 ug/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - other changes Skin and Appendages - sweating

REFERENCE :: FOMDAK Folia Medica (Naples). (Naples, Italy) V.1-57, 1915-74. Volume(issue)/page/year: 27,729,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,511,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1992,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1992,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56700 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 9,395,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5567 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2093 (estimated) No. of Female Employees: 1417 (estimated)

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盐酸妥拉唑林安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22

[ 危险品运输编码 ]:
2811

[ 海关编码 ]:
2933290090

盐酸妥拉唑林海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%