盐酸卤泛群
盐酸卤泛群用途
盐酸卤泛群名称
[ CAS 号 ]:
36167-63-2
[ 中文名 ]:
盐酸卤泛群
[ 英文名 ]:
Halofantrine hydrochloride
[中文别名 ]:
[英文别名 ]:
- UNII:2B7ENL644K
- MFCD00879136
- EINECS 252-895-4
- Halofantrine hydrochloride
- UNII:H77DL0Y630
盐酸卤泛群生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Malaria[1].HERG channel[2].
[参考文献]
盐酸卤泛群物理化学性质
[ 密度 ]:
1.244g/cm3
[ 沸点 ]:
596.2ºC at 760mmHg
[ 分子式 ]:
C26H31Cl3F3NO
[ 分子量 ]:
536.885
[ 闪点 ]:
314.4ºC
[ 精确质量 ]:
535.142334
[ PSA ]:
23.47000
[ LogP ]:
9.44630
[ 储存条件 ]:
2-8°C
盐酸卤泛群毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SF7790000
- CHEMICAL NAME :
- 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluo romethyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 36167-63-2
- LAST UPDATED :
- 199503
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C26-H30-Cl2-F3-N-O.Cl-H
- MOLECULAR WEIGHT :
- 536.93
- WISWESSER LINE NOTATION :
- L B666J DG FG IYQ2N4&4 MXFFF &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 7143 ug/kg
- TOXIC EFFECTS :
- Liver - liver function tests impaired Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 340,909,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 18 mg/kg/D
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,547,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 72 mg/kg/3D-I
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,1054,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 7143 ug/kg
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - urine volume decreased Blood - other hemolysis with or without anemia
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 340,909,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2050 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 240 mg/kg
- SEX/DURATION :
- female 6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,85,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,85,1984
盐酸卤泛群安全信息
[ 危害声明 ]:
H413
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危险品运输编码 ]:
NONH for all modes of transport
[ RTECS号 ]:
SF7790000
盐酸卤泛群文献
Chirality 24(7) , 558-65, (2012)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The pres...
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.Antimicrob. Agents Chemother. 56(3) , 1382-9, (2012)
Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700...
Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.Eur. J. Pharm. Sci. 47(2) , 347-51, (2012)
The purpose of this study was to evaluate if a rat model, based upon co-administration of the anion-exchanging resin, cholestyramine, could replace surgery when evaluating the importance of bile on dr...
推荐生产厂家/供应商:
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥389.0/1mg
¥1758.0/10mg
¥1167.0/5mg
¥需询单/1g
联系人:李先生
产品详情:Halofantrine (hydrochloride)
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥1513.0/5mg
¥2732.0/10mg
联系人:夏言
产品详情:[Perfemiker]Halofantrine hydrochloride,≥98%
查看所有供应商请点击:
相关化合物
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