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依替卡因-d9盐酸盐

依替卡因-d9盐酸盐用途

阿替卡因(盐酸)是一种长氨基酰胺局部麻醉剂[1]。

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依替卡因-d9盐酸盐名称

[ CAS 号 ]:
36637-19-1

[ 中文名 ]:
依替卡因-d9盐酸盐

[ 英文名 ]:
Etidocaine Hydrochloride

[英文别名 ]:

Duranest Hydrochloride
Etidocaine HCl
Etidocaine hydrochloride

依替卡因-d9盐酸盐生物活性

[ 描述 ]:

阿替卡因(盐酸)是一种长氨基酰胺局部麻醉剂[1]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

IGL-EDC制剂可诱导人成纤维细胞存活率显著增加[1]。细胞存活率测定细胞系：人成纤维细胞浓度：0、4、8、16、24 mM孵育时间：4、6和24 h结果：细胞存活率在(EDC)浓度下以时间依赖性方式下降。

[体内研究]

阿替卡因(脊髓注射,0.0075%,一次)未显示注射后神经功能缺损[2]。动物模型：成年Swiss Webster雄性小鼠[2]剂量：0.0075%给药：依替卡因(脊髓注射,0.007%,一次)结果：未显示注射后神经功能缺损。

[参考文献]

[1]. Oliveira, et al. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharmaceutical research vol. 35, 12 229. 10 Oct. 2018.

[2]. Langerman, L, et al. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model. Anesthesia and analgesia vol. 79,3 (1994): 490-4.

依替卡因-d9盐酸盐物理化学性质

[ 沸点 ]:
389.7ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₂₉ClN₂O

[ 分子量 ]:
312.87800

[ 闪点 ]:
189.5ºC

[ 精确质量 ]:
312.19700

[ PSA ]:
35.83000

[ LogP ]:
5.20390

依替卡因-d9盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EU5435000

CHEMICAL NAME :: 2',6'-Butyroxylidide, 2-(N-ethylpropylamino)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 36637-19-1

LAST UPDATED :: 199109

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H28-N2-O.Cl-H

MOLECULAR WEIGHT :: 312.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64400 ug/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity)

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 60,385,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 99 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58178 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,13,1976