5,10,15,20-四(1-甲基-4-吡啶基)卟啉四(对甲苯磺酸盐)

用途

TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体,可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂,在骨肉瘤细胞系中具有抗肿瘤作用。

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名称

[ CAS 号 ]:
36951-72-1

[ 中文名 ]:
Α,Β,Γ,Δ-四(1-甲基吡啶嗡-4-基)卟吩对甲苯磺酸盐

[ 英文名 ]:
5,10,15,20-Tetrakis(N-methyl-4-pyridyl)porphine tetratosylate

[中文别名 ]:

[英文别名 ]:

TMPyP4 tosylate
MFCD00013468
TMPyP ,Mg] [Fo
TMPYP
tmpyp tetratosylate

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> G-四链体

信号通路 >> 细胞周期/DNA损伤 >> 端粒酶

[ 靶点 ]

G-quadruplex[2] Telomerase[2]

[参考文献]

[1]. Chen H, et al. Insulin-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38.

[2]. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.

物理化学性质

[ 分子式 ]:
C₇₂H₆₆N₈O₁₂S₄

[ 分子量 ]:
1363.60

[ 精确质量 ]:
1362.368286

[ PSA ]:
334.14000

[ LogP ]:
10.08380

[ 外观性状 ]:
固体;Dark red to Dark purple to Dark blue powder to crystal

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
water: soluble50MM(lit.)

MSDS

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

合成路线

文献

Platinum nanoparticles on porphyrin functionalized graphene nanosheets as a superior catalyst for methanol electrooxidation.

Nanoscale 6(24) , 14999-15007, (2014)

A novel nanostructured catalyst of platinum nanoparticles supported on 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPyP) functionalized graphene (TMPyP-graphene) is ...

"Turn-off-on" fluorescent sensor for (N-methyl-4-pyridyl) porphyrin -DNA and G-quadruplex interactions based on ZnCdSe quantum dots.

Anal. Chim. Acta 888 , 131-7, (2015)

As a new detection model, the reversible fluorescence "turn-off-on" sensor based on quantum dots (QDs) has already been successfully employed in the detections of many biochemical materials, especiall...

The singlet-oxygen-sensitized delayed fluorescence in mammalian cells: a time-resolved microscopy approach.

Photochem. Photobiol. Sci. 14(4) , 700-13, (2015)

The present work provides a proof-of-concept that the singlet oxygen-sensitized delayed fluorescence (SOSDF) can be detected from individual living mammalian cells in a time-resolved microscopy experi...

更多文献

5,10,15,20-四(1-甲基-4-吡啶基)卟啉四(对甲苯磺酸盐)

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

文献

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