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氟代五氯丙酮

氟代五氯丙酮用途

【用途一】
荧光检测试剂，检测β-N-乙酰氨基己糖苷酶(β-N-acetylhexosaminidase),在pH 5.0缓冲液中λex 365 nm; λem 445 nm发出荧光。

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氟代五氯丙酮名称

[ CAS 号 ]:
37067-30-4

[ 中文名 ]:
4-甲基香豆素-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷

[ 英文名 ]:
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide

[中文别名 ]:

[英文别名 ]:

GLCNAC1-B-4MU
MFCD00065481
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide
4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide
EINECS 253-333-0
Methylumbelliferyl-N-acetyl-b-D-glucosaminide

氟代五氯丙酮生物活性

[ 描述 ]:

4-甲基伞形花序基-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷是N-乙酰-β-D-氨基葡萄糖苷酶的荧光底物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

通过从4-甲基伞形花序基-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷中去除末端β-糖苷结合的N-乙酰氨基葡萄糖和N-乙酰半乳糖胺残基的能力来评估酶的功能性[1]。

[参考文献]

[1]. Li J, et, al. Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis. Biochemistry (Mosc). 2012 Feb;77(2):194-200.

氟代五氯丙酮物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
732.2±60.0 °C at 760 mmHg

[ 熔点 ]:
208-210 °C

[ 分子式 ]:
C₁₈H₂₁NO₈

[ 分子量 ]:
379.361

[ 闪点 ]:
396.6±32.9 °C

[ 精确质量 ]:
379.126709

[ PSA ]:
138.46000

[ LogP ]:
0.34

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Light Sensitive - Protect from Light

[ 水溶解性 ]:
DMF: 20 mg/mL, clear, colorless

氟代五氯丙酮MSDS

氟代五氯丙酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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氟代五氯丙酮文献

Tay-Sachs disease heterozygote detection: use of a centrifugal analyser for automation of hexosaminidase assays with two different artificial substrates.

J. Med. Genet. 28(2) , 101-9, (1991)

An assay for measuring hexosaminidase A in serum and leucocytes is described in which a centrifugal analyser is used for automation of the enzyme assays after manual heat inactivation. The assay was u...

TNFalpha-induced macrophage death via caspase-dependent and independent pathways.

Apoptosis 14(3) , 320-32, (2009)

Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that followi...

A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate.

Electrophoresis 15(5) , 662-5, (1994)

A method for the detection of N-acetylglucosaminidase (GlcNAcase) activity has been developed by using 4-methyl-umbelliferyl-N-acetyl-D-glucosaminide (4-MU-GlcNAc) as substrate in crossed immunoelectr...

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