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雷公藤晋碱

雷公藤晋碱用途

Wilforgine 是 Tripterygium wilfordii Hook. F 中的生物活性倍半萜烯生物碱。Wilforgine 能诱导分离出丝状体幼虫肌肉的微结构和超微结构变化,其作用部位被认为是肌肉系统中的钙受体或通道。

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雷公藤晋碱名称

[ CAS 号 ]:
37239-47-7

[ 中文名 ]:
雷公藤吉碱

[ 英文名 ]:
Wilforgine

[中文别名 ]:

雷公藤精碱

[英文别名 ]:

Wilforgine

雷公藤晋碱生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ouyang XK, et al. Simultaneous determination of four sesquiterpene alkaloids in Tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography. Phytochem Anal. 2007 Jul-Aug;18(4):320-5.

[2]. Ma S, et al. Comparative studies on muscle microstructure and ultrastructure of Mythimna separata Walker treated with wilforgine and chlorantraniliprole. Ecotoxicol Environ Saf. 2018 Jan;147:1023-1034.

[3]. Gao X, et al. Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study. Phytomedicine. 2019 Feb 15;54:357-364.

雷公藤晋碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
859.9±65.0 °C at 760 mmHg

[ 熔点 ]:
211℃

[ 分子式 ]:
C₄₁H₄₇NO₁₉

[ 分子量 ]:
857.807

[ 闪点 ]:
473.8±34.3 °C

[ 精确质量 ]:
857.274231

[ PSA ]:
265.89000

[ LogP ]:
5.32

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
2-8C

雷公藤晋碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LF0195500

CHEMICAL NAME :: Evonimine, 8-(acetyloxy)-O(sup 2)-deacetyl-8-deoxo-O(sup 2)-(3-furanylcarbonyl)-, (8-alpha)-

CAS REGISTRY NUMBER :: 37239-47-7

BEILSTEIN REFERENCE NO. :: 0078231

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C41-H47-N-O19

MOLECULAR WEIGHT :: 857.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 474 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,266,1990